ACOX3

Peroxisomal acyl-coenzyme A oxidase 3 is an enzyme that in humans is encoded by the ACOX3 gene.[5][6]

ACOX3
Identifiers
Aliases	ACOX3, acyl-CoA oxidase 3, pristanoyl
External IDs	OMIM: 603402 MGI: 1933156 HomoloGene: 37792 GeneCards: ACOX3
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 8,366,282 bp[1] End 8,440,723 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 35,740,384 bp[2] End 35,772,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right lobe of liver skin of abdomen minor salivary gland sural nerve vagina body of pancreas body of stomach stromal cell of endometrium ascending aorta Top expressed in spermatocyte secondary oocyte proximal tubule spermatid lip superior frontal gyrus kidney duodenum cerebellar cortex spermatogonium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity, acting on the CH-CH group of donors acyl-CoA oxidase activity oxidoreductase activity signaling receptor binding pristanoyl-CoA oxidase activity FAD binding acyl-CoA dehydrogenase activity flavin adenine dinucleotide binding fatty acid binding Cellular component membrane peroxisome peroxisomal matrix mitochondrion cytosol Biological process lipid metabolism fatty acid metabolic process fatty acid beta-oxidation using acyl-CoA oxidase fatty acid beta-oxidation metabolism fatty acid beta-oxidation using acyl-CoA dehydrogenase protein targeting to peroxisome lipid homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8310 80911 Ensembl ENSG00000087008 ENSMUSG00000029098 UniProt O15254 Q9EPL9 RefSeq (mRNA) NM_001101667 NM_003501 NM_030721 NM_001357018 NM_001357019 NM_001357020 RefSeq (protein) NP_001095137 NP_003492 NP_001362712 NP_001362713 NP_001362714 NP_001362715 NP_001362716 NP_001362717 NP_001362718 NP_001362719 NP_109646 NP_001343947 NP_001343948 NP_001343949 Location (UCSC) Chr 4: 8.37 – 8.44 Mb Chr 5: 35.74 – 35.77 Mb PubMed search [3] [4]
Wikidata
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Acyl-Coenzyme A oxidase 3 also known as pristanoyl-CoA oxidase (ACOX3) is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in the liver such that its mRNA was undetectable by routine Northern-blot analysis, by immunoblotting for its product, or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined.[6]