ACRV1

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.[5][6][7]

ACRV1
Identifiers
AliasesACRV1, D11S4365, SP-10, SPACA2, acrosomal vesicle protein 1
External IDsOMIM: 102525 MGI: 104590 HomoloGene: 1219 GeneCards: ACRV1
Orthologs
SpeciesHumanMouse
Entrez

56

11451

Ensembl

ENSG00000134940

ENSMUSG00000032110

UniProt

P26436

P50289

RefSeq (mRNA)

NM_007391

RefSeq (protein)

NP_001603
NP_064454
NP_064492
NP_064493

NP_031417

Location (UCSC)Chr 11: 125.67 – 125.68 MbChr 9: 36.6 – 36.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000134940 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032110 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10". Biol Reprod. 42 (4): 693–701. doi:10.1095/biolreprod42.4.693. PMID 1693291.
  6. Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9. doi:10.1006/geno.1993.1496. PMID 8288254.
  7. "Entrez Gene: ACRV1 acrosomal vesicle protein 1".

Further reading


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