ACSL3

Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.[5]

ACSL3
Identifiers
AliasesACSL3, ACS3, FACL3, PRO2194, acyl-CoA synthetase long-chain family member 3, acyl-CoA synthetase long chain family member 3, LACS3, LACS 3
External IDsOMIM: 602371 MGI: 1921455 HomoloGene: 3278 GeneCards: ACSL3
Orthologs
SpeciesHumanMouse
Entrez

2181

74205

Ensembl

ENSG00000123983

ENSMUSG00000032883

UniProt

O95573

Q9CZW4

RefSeq (mRNA)

NM_004457
NM_203372
NM_001354158
NM_001354159

NM_001033606
NM_001136222
NM_028817

RefSeq (protein)

NP_004448
NP_976251
NP_001341087
NP_001341088

NP_001028778
NP_001129694
NP_083093

Location (UCSC)Chr 2: 222.86 – 222.94 MbChr 1: 78.64 – 78.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000123983 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032883 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ACSL3 acyl-CoA synthetase long-chain family member 3".

Further reading

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