ADAMTSL1

ADAMTS-like protein 1 is a protein that in humans is encoded by the ADAMTSL1 gene.[5][6][7]

ADAMTSL1
Identifiers
AliasesADAMTSL1, ADAMTSL-1, ADAMTSR1, C9orf94, PUNCTIN, ADAMTS like 1
External IDsOMIM: 609198 MGI: 1924989 HomoloGene: 64642 GeneCards: ADAMTSL1
Orthologs
SpeciesHumanMouse
Entrez

92949

77739

Ensembl

ENSG00000178031

ENSMUSG00000066113

UniProt

Q8N6G6

Q8BLI0

RefSeq (mRNA)

NM_001040272
NM_052866
NM_139238
NM_139264

NM_029967
NM_172542
NM_001368621

RefSeq (protein)

NP_001035362
NP_443098

NP_084243
NP_001355550

Location (UCSC)Chr 9: 17.91 – 18.91 MbChr 4: 85.43 – 86.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a secreted protein resembling members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the propeptide region and the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000178031 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000066113 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. Hirohata S, Wang LW, Miyagi M, Yan L, Seldin MF, Keene DR, Crabb JW, Apte SS (Apr 2002). "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix". J Biol Chem. 277 (14): 12182–9. doi:10.1074/jbc.M109665200. PMID 11805097.
  7. "Entrez Gene: ADAMTSL1 ADAMTS-like 1".

Further reading


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