ADARB2

Double-stranded RNA-specific editase B2 is an enzyme that in humans is encoded by the ADARB2 gene.[5][6][7]

ADARB2
Identifiers
AliasesADARB2, ADAR3, RED2, adenosine deaminase, RNA specific B2 (inactive), adenosine deaminase RNA specific B2 (inactive)
External IDsOMIM: 602065 MGI: 2151118 HomoloGene: 10276 GeneCards: ADARB2
Orthologs
SpeciesHumanMouse
Entrez

105

94191

Ensembl

ENSG00000185736

ENSMUSG00000052551

UniProt

Q9NS39

Q9JI20

RefSeq (mRNA)

NM_018702

NM_001289530
NM_052977

RefSeq (protein)

NP_061172

NP_001276459
NP_443209

Location (UCSC)Chr 10: 1.18 – 1.74 MbChr 13: 8.25 – 8.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

RNA-editing deaminase-2 (RED2, or ADARB2) is a member of the double-stranded RNA (dsRNA) adenosine deaminase family of RNA-editing enzymes. Adenosine deamination of pre-mRNA results in a change in the amino acid sequence of the gene product, which differs from that predicted by the genomic DNA sequence. Other members of this family include DRADA (ADAR) and RED1 (ADARB1).[5][7]

Unlike ADAR1 and ADAR2, ADAR3 has demonstrated no editing ability in vitro. It has been shown to suppress 5-HT2C RNA editing in vitro through a yet unknown mechanism, and may thus work as a negative regulator.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000185736 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052551 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mittaz L, Antonarakis SE, Higuchi M, Scott HS (Sep 1997). "Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15". Human Genetics. 100 (3–4): 398–400. doi:10.1007/s004390050523. PMID 9272162. S2CID 13098381.
  6. Chen CX, Cho DS, Wang Q, Lai F, Carter KC, Nishikura K (May 2000). "A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains". RNA. 6 (5): 755–67. doi:10.1017/S1355838200000170. PMC 1369955. PMID 10836796.
  7. "Entrez Gene: ADARB2 adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)".
  8. Hong HQ, Lin JS, Chen L (Feb 2015). "Regulatory factors governing Adenosine-to-Inosine (A-to-I) RNA editing". Bioscience Reports. 35 (2): 1–8. doi:10.1042/BSR20140190. PMC 4381283. PMID 25662729.

Further reading


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