ADD2

Beta-adducin is a protein that in humans is encoded by the ADD2 gene.[5][6]

ADD2
Identifiers
AliasesADD2, ADDB, adducin 2
External IDsOMIM: 102681 MGI: 87919 HomoloGene: 1221 GeneCards: ADD2
Orthologs
SpeciesHumanMouse
Entrez

119

11519

Ensembl

ENSG00000075340

ENSMUSG00000030000

UniProt

P35612

Q9QYB8

RefSeq (mRNA)
RefSeq (protein)

NP_001171983
NP_001171984
NP_001608
NP_059516
NP_059522

Location (UCSC)Chr 2: 70.61 – 70.77 MbChr 6: 86.01 – 86.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta, and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.

While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains.

The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3' end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.[6]

Interactions

ADD2 has been shown to interact with FYN.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000075340 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030000 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Joshi R, Gilligan DM, Otto E, McLaughlin T, Bennett V (Nov 1991). "Primary structure and domain organization of human alpha and beta adducin". J Cell Biol. 115 (3): 665–75. doi:10.1083/jcb.115.3.665. PMC 2289184. PMID 1840603.
  6. "Entrez Gene: ADD2 adducin 2 (beta)".
  7. Shima T, Okumura N, Takao T, Satomi Y, Yagi T, Okada M, Nagai K (November 2001). "Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin". J. Biol. Chem. 276 (45): 42233–40. doi:10.1074/jbc.M102699200. PMID 11526103.

Further reading


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