AGH-107

AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5HT7 serotonin receptor.[1] AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the related central nervous system targets. AGH-107 was found to reverse the impairment in novel object recognition caused by MK-801 in mice. The relatively short half-life in rodents inhibited its use as a molecular probe.

AGH-107
Identifiers
  • 3-(3-ethylimidazol-4-yl)-5-iodo-1H-indole
PubChem CID
Chemical and physical data
FormulaC13H12IN3
Molar mass337.164 g·mol−1
3D model (JSmol)
  • CCn1cncc1-c1c[nH]c2ccc(I)cc12

See also

References
  1. Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, et al. (May 2017). "7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol". Scientific Reports. 7 (1): 1444. doi:10.1038/s41598-017-00822-4. PMC 5431432. PMID 28473721.
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