AGPAT3

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene.[5] The protein encoded by this gene is an acyltransferase (specifically, 1-acylglycerol-3-phosphate O-acyltransferase) that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.[5]

AGPAT3
Identifiers
AliasesAGPAT3, LPAAT-GAMMA1, LPAAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3
External IDsOMIM: 614794 MGI: 1336186 HomoloGene: 10591 GeneCards: AGPAT3
Orthologs
SpeciesHumanMouse
Entrez

56894

28169

Ensembl

ENSG00000160216

ENSMUSG00000001211

UniProt

Q9NRZ7

Q9D517

RefSeq (mRNA)

NM_001037553
NM_020132
NM_001369878
NM_001369880
NM_001369881

NM_053014

RefSeq (protein)

NP_001032642
NP_064517
NP_001356807
NP_001356809
NP_001356810

Location (UCSC)Chr 21: 43.87 – 43.99 MbChr 10: 78.11 – 78.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of AGPAT3 function. A conditional knockout mouse line, called Agpat3tm1a(EUCOMM)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on mutant mice and one significant abnormality was observed.[8] Few homozygous mutant animals survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these.[8]

References
  1. GRCh38: Ensembl release 89: ENSG00000160216 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001211 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3".
  6. "Salmonella infection data for Agpat3". Wellcome Trust Sanger Institute.
  7. "Citrobacter infection data for Agpat3". Wellcome Trust Sanger Institute.
  8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. "International Knockout Mouse Consortium".
  11. "Mouse Genome Informatics".
  12. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  15. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.