AGTRAP

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.[5][6]

AGTRAP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGTRAP, ATRAP, angiotensin II receptor associated protein
External IDsOMIM: 608729 MGI: 1339977 HomoloGene: 7621 GeneCards: AGTRAP
Orthologs
SpeciesHumanMouse
Entrez

57085

11610

Ensembl

ENSG00000177674

ENSMUSG00000029007

UniProt

Q6RW13

Q9WVK0

RefSeq (mRNA)

NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350

NM_001301281
NM_009642

RefSeq (protein)

NP_001035284
NP_001035285
NP_001035286
NP_001035287
NP_065083

NP_001288210
NP_033772

Location (UCSC)Chr 1: 11.74 – 11.75 MbChr 4: 148.16 – 148.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[6]

Interactions

AGTRAP has been shown to interact with GNB2L1.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000177674 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029007 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
  6. "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.