AGXT2
The human AGXT2 gene encodes the protein Alanine—glyoxylate aminotransferase 2. [5]
| AGXT2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | AGXT2, AGT2, DAIBAT, alanine--glyoxylate aminotransferase 2, BAIBA | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612471 MGI: 2146052 HomoloGene: 12887 GeneCards: AGXT2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| EC number | 2.6.1.40 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.[6]
References
- GRCh38: Ensembl release 89: ENSG00000113492 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000089678 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Alanine--glyoxylate aminotransferase 2". Retrieved 2014-01-12.
- [provided by RefSeq, Dec 2008]. ##Evidence-Data-START## Transcript exon combination :: AJ292204.1, AB193309.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025084, ERS025088 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##
Further reading
- Lee IS, Muragaki Y, Ideguchi T, Hase T, Tsuji M, Ooshima A, et al. (April 1995). "Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney". Journal of Biochemistry. 117 (4): 856–862. doi:10.1093/oxfordjournals.jbchem.a124787. PMID 7592550.
- Nicholson G, Rantalainen M, Li JV, Maher AD, Malmodin D, Ahmadi KR, et al. (September 2011). Barsh GS (ed.). "A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection". PLOS Genetics. 7 (9): e1002270. doi:10.1371/journal.pgen.1002270. PMC 3169529. PMID 21931564.
- Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, Michael K, et al. (June 2011). "A genome-wide association study of metabolic traits in human urine". Nature Genetics. 43 (6): 565–569. doi:10.1038/ng.837. PMID 21572414. S2CID 28694666.
- Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR (February 2010). "Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production". The Journal of Biological Chemistry. 285 (8): 5385–5391. doi:10.1074/jbc.M109.091280. PMC 2820767. PMID 20018850.
- Baker PR, Cramer SD, Kennedy M, Assimos DG, Holmes RP (November 2004). "Glycolate and glyoxylate metabolism in HepG2 cells". American Journal of Physiology. Cell Physiology. 287 (5): C1359–C1365. doi:10.1152/ajpcell.00238.2004. PMID 15240345.
- Danpure CJ (August 2005). "Primary hyperoxaluria: from gene defects to designer drugs?". Nephrology, Dialysis, Transplantation. 20 (8): 1525–1529. doi:10.1093/ndt/gfh923. PMID 15956068.
- Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahaye M, et al. (December 2012). "Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure". Arteriosclerosis, Thrombosis, and Vascular Biology. 32 (12): 2892–2900. doi:10.1161/ATVBAHA.112.254078. PMID 23023372.
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