AHNAK

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.[5][6][7] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.[8] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. [9]

AHNAK
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesAHNAK, AHNAKRS, AHNAK nucleoprotein, PM227
External IDsOMIM: 103390 MGI: 1316648 HomoloGene: 67425 GeneCards: AHNAK
Orthologs
SpeciesHumanMouse
Entrez

79026

66395

Ensembl

ENSG00000124942

ENSMUSG00000069833

UniProt

Q09666

n/a

RefSeq (mRNA)

NM_001620
NM_024060
NM_001346445
NM_001346446

NM_001039959
NM_001286518
NM_009643
NM_175108

RefSeq (protein)

NP_001333374
NP_001333375
NP_001611
NP_076965

n/a

Location (UCSC)Chr 11: 62.43 – 62.56 MbChr 19: 8.97 – 9.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

AHNAK has been shown to interact with S100B.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000124942 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069833 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. James MR, Richard CW, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A (September 1994). "A radiation hybrid map of 506 STS markers spanning human chromosome 11". Nature Genetics. 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395. S2CID 21392416.
  6. Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H (August 2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton". FASEB Journal. 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988. S2CID 12413536.
  7. "Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)".
  8. Hieda Y, Tsukita S, Tsukita S (October 1989). "A new high molecular mass protein showing unique localization in desmosomal plaque". The Journal of Cell Biology. 109 (4 Pt 1): 1511–8. doi:10.1083/jcb.109.4.1511. PMC 2115823. PMID 2677021.
  9. Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells". Cancer Research. 70 (9): 3780–90. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789.
  10. Gentil BJ, Delphin C, Mbele GO, Deloulme JC, Ferro M, Garin J, Baudier J (June 2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B". The Journal of Biological Chemistry. 276 (26): 23253–61. doi:10.1074/jbc.M010655200. PMID 11312263.

Further reading


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