WDR1

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.[5][6]

WDR1
Identifiers
AliasesWDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDsOMIM: 604734 MGI: 1337100 HomoloGene: 6628 GeneCards: WDR1
Orthologs
SpeciesHumanMouse
Entrez

9948

22388

Ensembl

ENSG00000071127

ENSMUSG00000005103

UniProt

O75083

O88342

RefSeq (mRNA)

NM_005112
NM_017491

NM_011715

RefSeq (protein)

NP_005103
NP_059830

NP_035845

Location (UCSC)Chr 4: 10.07 – 10.12 MbChr 5: 38.68 – 38.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000071127 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005103 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID 10036186.
  6. "Entrez Gene: WDR1 WD repeat domain 1".

Further reading


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