AKAP10

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.[4][5]

AKAP10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKAP10, AKAP-10, D-AKAP-2, D-AKAP2, PRKA10, A-kinase anchoring protein 10
External IDsOMIM: 604694 MGI: 1890218 HomoloGene: 32452 GeneCards: AKAP10
Orthologs
SpeciesHumanMouse
Entrez

11216

56697

Ensembl

n/a

ENSMUSG00000047804

UniProt

O43572

O88845

RefSeq (mRNA)

NM_007202
NM_001330152

NM_019921

RefSeq (protein)

NP_001317081
NP_009133

NP_064305

Location (UCSC)n/aChr 11: 61.76 – 61.82 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.[5]

Interactions

AKAP10 has been shown to interact with PDZK1[6] and PRKAR1A.[4][7]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000047804 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. Bibcode:1997PNAS...9411184H. doi:10.1073/pnas.94.21.11184. PMC 23409. PMID 9326583.
  5. "Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10".
  6. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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