AKAP2

A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene.[3][4] It is likely involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.[5] Malfunction of AKAP2 is associated with Kallmann Syndrome.

AKAP2
Identifiers
AliasesAKAP2, AKAP-2, AKAPKL, PRKA2, A-kinase anchoring protein 2, MISP2
External IDsMGI: 1306795 HomoloGene: 100376 GeneCards: AKAP2
Orthologs
SpeciesHumanMouse
Entrez

11217

11641

Ensembl

n/a

n/a

UniProt

Q9Y2D5

O54931

RefSeq (mRNA)

NM_001198656
NM_001004065
NM_001136562

NM_001035532
NM_001035533
NM_009649

RefSeq (protein)

NP_009134
NP_671492

NP_033779
NP_001291473
NP_766456

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

AKAP2 has been shown to interact with PRKAR2A.[6][7]

References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
  4. "Entrez Gene: AKAP2 A kinase (PRKA) anchor protein 2".
  5. "UniProt". www.uniprot.org. Retrieved 2023-10-21.
  6. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. Bibcode:2003PNAS..100.4445A. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
  7. Dong F, Feldmesser M, Casadevall A, Rubin CS (Mar 1998). "Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein". J. Biol. Chem. 273 (11): 6533–41. doi:10.1074/jbc.273.11.6533. PMID 9497389.

Further reading


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