AKAP2
A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene.[3][4] It is likely involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP.[5] Malfunction of AKAP2 is associated with Kallmann Syndrome.
| AKAP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | AKAP2, AKAP-2, AKAPKL, PRKA2, A-kinase anchoring protein 2, MISP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1306795 HomoloGene: 100376 GeneCards: AKAP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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References
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
- "Entrez Gene: AKAP2 A kinase (PRKA) anchor protein 2".
- "UniProt". www.uniprot.org. Retrieved 2023-10-21.
- Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. Bibcode:2003PNAS..100.4445A. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
- Dong F, Feldmesser M, Casadevall A, Rubin CS (Mar 1998). "Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein". J. Biol. Chem. 273 (11): 6533–41. doi:10.1074/jbc.273.11.6533. PMID 9497389.
External links
- Human AKAP2 genome location and AKAP2 gene details page in the UCSC Genome Browser.
Further reading
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Alto NM, Soderling SH, Hoshi N, et al. (2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. Bibcode:2003PNAS..100.4445A. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
- Kammerer S, Burns-Hamuro LL, Ma Y, et al. (2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4066–71. Bibcode:2003PNAS..100.4066K. doi:10.1073/pnas.2628028100. PMC 153049. PMID 12646697.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hu B, Copeland NG, Gilbert DJ, et al. (2001). "The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative". Biochem. Biophys. Res. Commun. 285 (5): 1369–76. doi:10.1006/bbrc.2001.5329. PMID 11478809.
- Dong F, Feldmesser M, Casadevall A, Rubin CS (1998). "Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein". J. Biol. Chem. 273 (11): 6533–41. doi:10.1074/jbc.273.11.6533. PMID 9497389.
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