AKAP7

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.[5][6]

AKAP7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKAP7, AKAP15, AKAP18, A-kinase anchoring protein 7
External IDsOMIM: 604693 MGI: 1859150 HomoloGene: 49463 GeneCards: AKAP7
Orthologs
SpeciesHumanMouse
Entrez

9465

432442

Ensembl

ENSG00000118507

ENSMUSG00000039166

UniProt

O43687
Q9P0M2

O55074
Q7TN79

RefSeq (mRNA)

NM_018747
NM_001347460
NM_001379238
NM_001379239
NM_001379240

RefSeq (protein)

NP_004833
NP_057461
NP_619539
NP_001363499
NP_057461.2

Location (UCSC)Chr 6: 131.14 – 131.28 MbChr 10: 25.04 – 25.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000118507 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039166 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
  6. "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

Further reading


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