AKAP8

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.[5][6]

AKAP8
Identifiers
AliasesAKAP8, AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchoring protein 8
External IDsOMIM: 604692 MGI: 1928488 HomoloGene: 4278 GeneCards: AKAP8
Orthologs
SpeciesHumanMouse
Entrez

10270

56399

Ensembl

ENSG00000105127

ENSMUSG00000024045

UniProt

O43823

Q9DBR0

RefSeq (mRNA)

NM_005858

NM_019774
NM_001357760

RefSeq (protein)

NP_005849

NP_062748
NP_001344689

Location (UCSC)Chr 19: 15.35 – 15.38 MbChr 17: 32.52 – 32.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.[6]

Interactions

AKAP8 has been demonstrated to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000105127 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024045 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res. 238 (2): 305–16. doi:10.1006/excr.1997.3855. PMID 9473338.
  6. "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8".
  7. Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (Mar 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.
  8. Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM (May 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. doi:10.1074/jbc.M101171200. PMID 11279182.
  9. Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. doi:10.1074/jbc.M300765200. PMID 12740381.
  10. Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
  11. Collas P, Le Guellec K, Taskén K (Dec 1999). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC 2168084. PMID 10601332.

Further reading


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