ALOX15B

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[5][6] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

ALOX15B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesALOX15B, 15-LOX-2, arachidonate 15-lipoxygenase, type B, arachidonate 15-lipoxygenase type B
External IDsOMIM: 603697 MGI: 1098228 HomoloGene: 886 GeneCards: ALOX15B
Orthologs
SpeciesHumanMouse
Entrez

247

11688

Ensembl

ENSG00000179593

ENSMUSG00000020891

UniProt

O15296

O35936

RefSeq (mRNA)

NM_001141
NM_001039130
NM_001039131

NM_009661

RefSeq (protein)

NP_001034219
NP_001034220
NP_001132

NP_033791

Location (UCSC)Chr 17: 8.04 – 8.05 MbChr 11: 69.07 – 69.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.[5] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.[5] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000179593 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020891 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brash AR, Boeglin WE, Chang MS (Jun 1997). "Discovery of a second 15S-lipoxygenase in humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6148–52. Bibcode:1997PNAS...94.6148B. doi:10.1073/pnas.94.12.6148. PMC 21017. PMID 9177185.
  6. "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B".

Further reading


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