ALPK1

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.[5][6][7]

ALPK1
Identifiers
AliasesALPK1, 8430410J10Rik, LAK, alpha kinase 1, ROSAH
External IDsOMIM: 607347 MGI: 1918731 HomoloGene: 11849 GeneCards: ALPK1
Orthologs
SpeciesHumanMouse
Entrez

80216

71481

Ensembl

ENSG00000073331

ENSMUSG00000028028

UniProt

Q96QP1

Q9CXB8

RefSeq (mRNA)

NM_001102406
NM_001253884
NM_025144

NM_027808

RefSeq (protein)

NP_001095876
NP_001240813
NP_079420

n/a

Location (UCSC)Chr 4: 112.29 – 112.44 MbChr 3: 127.46 – 127.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000073331 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028028 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ryazanov AG, Pavur KS, Dorovkov MV (Mar 1999). "Alpha-kinases: a new class of protein kinases with a novel catalytic domain". Curr Biol. 9 (2): R43–5. doi:10.1016/S0960-9822(99)80006-2. PMID 10021370. S2CID 34505206.
  6. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  7. "Entrez Gene: ALPK1 alpha-kinase 1".

Further reading


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