Annexin A11

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.[5][6][7]

ANXA11
Identifiers
AliasesANXA11, ANX11, CAP50, annexin A11, CAP-50, ALS23, IBMWMA
External IDsOMIM: 602572 MGI: 108481 HomoloGene: 22759 GeneCards: ANXA11
Orthologs
SpeciesHumanMouse
Entrez

311

11744

Ensembl

ENSG00000122359

ENSMUSG00000021866

UniProt

P50995

P97384

RefSeq (mRNA)

NM_013469

RefSeq (protein)

NP_038497

Location (UCSC)Chr 10: 80.15 – 80.21 MbChr 14: 25.84 – 25.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified.[7]

Interactions

ANXA11 has been shown to interact with PDCD6[8] and ALG2.[9]

Clinical significance

It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in schizophrenia and contribute to pathomechanisms of this disorder.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000122359 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021866 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Misaki Y, Pruijn GJ, van der Kemp AW, van Venrooij WJ (Feb 1994). "The 56K autoantigen is identical to human annexin XI". The Journal of Biological Chemistry. 269 (6): 4240–6. doi:10.1016/S0021-9258(17)41769-8. PMID 7508441.
  6. Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1998). "Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins". Genomics. 48 (1): 100–10. doi:10.1006/geno.1997.5148. PMID 9503022.
  7. "Entrez Gene: ANXA11 annexin A11".
  8. Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochemical and Biophysical Research Communications. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID 11883939.
  9. Satoh H, Nakano Y, Shibata H, Maki M (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID 12445460.
  10. Ghazaryan H (Jul 2013). "Annexin 11 expression pattern in schizophrenia". Electronic Journal of Natural Sciences. 21 (2): 74–76.

Further reading


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