AP2A2

AP2A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
Identifiers
Aliases	AP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
External IDs	OMIM: 607242 MGI: 101920 HomoloGene: 5335 GeneCards: AP2A2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	1,012,245 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	141,212,924 bp[2]
RNA expression pattern
	Top expressed in
	spleen; ; superior frontal gyrus; ; sural nerve; ; subcutaneous adipose tissue; ; prefrontal cortex; ; canal of the cervix; ; pituitary gland; ; ganglionic eminence; ; upper lobe of left lung; ; kidney;
	Top expressed in
	entorhinal cortex; ; medullary collecting duct; ; superior frontal gyrus; ; cerebellar cortex; ; habenula; ; hippocampus proper; ; supraoptic nucleus; ; Region I of hippocampus proper; ; amygdala; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	clathrin adaptor activity; protein binding; protein kinase binding; lipid binding; protein domain specific binding; disordered domain specific binding; molecular function;
Cellular component	endocytic vesicle membrane; cytosol; clathrin-coated endocytic vesicle membrane; membrane; plasma membrane; endolysosome membrane; membrane coat; clathrin-coated pit; AP-2 adaptor complex; clathrin adaptor complex; secretory granule membrane; cytoplasmic vesicle; ficolin-1-rich granule membrane; clathrin-coated endocytic vesicle;
Biological process	endocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; ephrin receptor signaling pathway; mitigation of host defenses by virus; clathrin-dependent endocytosis; protein transport; intracellular protein transport; vesicle-mediated transport; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; neutrophil degranulation; membrane organization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport;
	Sources:Amigo / QuickGO
Orthologs
	161
	11772
	ENSG00000281385; ENSG00000280759; ENSG00000183020
	ENSMUSG00000002957
	O94973
	P17427
	NM_001242837; NM_012305
	NM_007459; NM_001357068
	NP_001229766; NP_036437
	NP_031485; NP_001343997
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.[5][6][7]

Interactions

AP2A2 has been shown to interact with EPN1[8] and SHC1.[9]

References

ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002957 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.
"Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".
Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.

Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
David C, McPherson PS, Mundigl O, de Camilli P (Jan 1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 331–5. doi:10.1073/pnas.93.1.331. PMC 40232. PMID 8552632.
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.
Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (May 1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein". The Journal of Biological Chemistry. 271 (20): 12111–6. doi:10.1074/jbc.271.20.12111. PMID 8662627.
van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM (Feb 1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin". The Journal of Cell Biology. 136 (4): 811–21. doi:10.1083/jcb.136.4.811. PMC 2132490. PMID 9049247.
Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (Jun 1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform". The Journal of Biological Chemistry. 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC 103959. PMID 9882340.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Traub LM, Downs MA, Westrich JL, Fremont DH (Aug 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 8907–12. Bibcode:1999PNAS...96.8907T. doi:10.1073/pnas.96.16.8907. PMC 17706. PMID 10430869.
Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". The Journal of Cell Biology. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Slepnev VI, Ochoa GC, Butler MH, De Camilli P (Jun 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". The Journal of Biological Chemistry. 275 (23): 17583–9. doi:10.1074/jbc.M910430199. PMID 10748223.
Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (Aug 2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis" (PDF). Journal of Cell Science. 113 (16): 2837–44. doi:10.1242/jcs.113.16.2837. PMID 10910768.

External links

Human AP2A2 genome location and AP2A2 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002957 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9700202-5] Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.

[pmid2564002-6] Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.

[entrez-7] "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".

[pmid9723620-8] Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.

[pmid8617812-9] Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins". The Journal of Biological Chemistry. 271 (9): 5265–9. doi:10.1074/jbc.271.9.5265. PMID 8617812.

AP2A2

Interactions

References

Further reading

External links