APBB2

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.[5][6][7]

APBB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
External IDsOMIM: 602710 MGI: 108405 HomoloGene: 32079 GeneCards: APBB2
Orthologs
SpeciesHumanMouse
Entrez

323

11787

Ensembl

ENSG00000163697

ENSMUSG00000029207

UniProt

Q92870

Q9DBR4

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 40.81 – 41.22 MbChr 5: 66.46 – 66.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000163697 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029207 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
  6. Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.
  7. "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

Further reading


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