APOA1BP

NAXE
Identifiers
Aliases	NAXE, AIBP, YJEFN1, APOA1BP, NAD(P)HX epimerase, PEBEL
External IDs	OMIM: 608862 MGI: 2180167 HomoloGene: 70948 GeneCards: NAXE
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	156,609,507 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	87,965,802 bp[2]
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; prefrontal cortex; ; corpus epididymis; ; anterior pituitary; ; kidney; ; right adrenal gland; ; left adrenal gland; ; substantia nigra; ; right ventricle; ; cingulate gyrus;
	Top expressed in
	facial motor nucleus; ; utricle; ; right lung lobe; ; proximal tubule; ; external carotid artery; ; left lobe of liver; ; internal carotid artery; ; epithelium of stomach; ; medial ganglionic eminence; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; NADHX epimerase activity; protein binding; protein homodimerization activity; isomerase activity; metal ion binding; NADPHX epimerase activity;
Cellular component	cell body; extracellular region; cilium; extracellular exosome; intracellular membrane-bounded organelle; mitochondrion; nucleus; nucleoplasm; mitochondrial matrix; extracellular space; cytosol;
Biological process	protein homotetramerization; NAD biosynthesis via nicotinamide riboside salvage pathway; nicotinamide nucleotide metabolic process; NADH metabolic process; NADP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	128240
	246703
	ENSG00000163382
	ENSMUSG00000028070
	Q8NCW5
	Q8K4Z3
	NM_144772
	NM_144897
	NP_658985
	NP_659146
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein A-I-binding protein also known as APOA1BP is a protein that in humans is encoded by the APOA1BP gene.[5]

Function

APOA1BP binds to APOA1, APOA2, and high-density lipoprotein (HDL).[5] In addition, APOA1BP appears to play a role in sperm capacitation.[6]

References

GRCh38: Ensembl release 89: ENSG00000163382 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028070 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ritter M, Buechler C, Boettcher A, Barlage S, Schmitz-Madry A, Orsó E, Bared SM, Schmiedeknecht G, Baehr CH, Fricker G, Schmitz G (May 2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I". Genomics. 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.
Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC (May 2008). "Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation". Endocrinology. 149 (5): 2108–20. doi:10.1210/en.2007-0582. PMC 2329272. PMID 18202122.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163382 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028070 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11991719-5] Ritter M, Buechler C, Boettcher A, Barlage S, Schmitz-Madry A, Orsó E, Bared SM, Schmiedeknecht G, Baehr CH, Fricker G, Schmitz G (May 2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I". Genomics. 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.

[pmid18202122-6] Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC (May 2008). "Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation". Endocrinology. 149 (5): 2108–20. doi:10.1210/en.2007-0582. PMC 2329272. PMID 18202122.