ARG2

Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene.[5]

ARG2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARG2, arginase 2
External IDsOMIM: 107830 MGI: 1330806 HomoloGene: 906 GeneCards: ARG2
Orthologs
SpeciesHumanMouse
Entrez

384

11847

Ensembl

ENSG00000081181

ENSMUSG00000021125

UniProt

P78540

O08691

RefSeq (mRNA)

NM_001172

NM_009705

RefSeq (protein)

NP_001163

NP_033835

Location (UCSC)Chr 14: 67.62 – 67.65 MbChr 12: 79.18 – 79.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.

References

  1. GRCh38: Ensembl release 89: ENSG00000081181 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021125 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Arginase, type II".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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