ARHGAP4

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.[5][6] It has been shown to regulate cell motility and axonal outgrowth in vitro.[7]

ARHGAP4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDsOMIM: 300023 MGI: 2159577 HomoloGene: 20403 GeneCards: ARHGAP4
Orthologs
SpeciesHumanMouse
Entrez

393

171207

Ensembl

ENSG00000089820

ENSMUSG00000031389

UniProt

P98171

n/a

RefSeq (mRNA)

NM_001666
NM_001164741

NM_001162423
NM_001162424
NM_138630

RefSeq (protein)

NP_001158213
NP_001657

n/a

Location (UCSC)Chr X: 153.91 – 153.93 MbChr X: 72.94 – 72.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000089820 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031389 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A. 93 (2): 695–9. Bibcode:1996PNAS...93..695T. doi:10.1073/pnas.93.2.695. PMC 40115. PMID 8570618.
  6. "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4".
  7. Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth". Molecular and Cellular Neurosciences. 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC 2111057. PMID 17804252.

Further reading


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