ARHGAP9

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.[5][6]

ARHGAP9
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDsOMIM: 610576 MGI: 2143764 HomoloGene: 13041 GeneCards: ARHGAP9
Orthologs
SpeciesHumanMouse
Entrez

64333

216445

Ensembl

ENSG00000123329

ENSMUSG00000040345

UniProt

Q9BRR9

n/a

RefSeq (mRNA)

NM_001285785
NM_146011
NM_001359656
NM_001359657

RefSeq (protein)

n/a

Location (UCSC)Chr 12: 57.47 – 57.49 MbChr 10: 127.16 – 127.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000123329 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040345 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
  6. "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.