ARHGEF3

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.[5]

ARHGEF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDsOMIM: 612115 MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3
Orthologs
SpeciesHumanMouse
Entrez

50650

71704

Ensembl

ENSG00000163947

ENSMUSG00000021895

UniProt

Q9NR81

Q91X46

RefSeq (mRNA)

NM_001289686
NM_001289687
NM_001289688
NM_027871

RefSeq (protein)

NP_001276615
NP_001276616
NP_001276617
NP_082147

Location (UCSC)Chr 3: 56.73 – 57.08 MbChr 14: 26.84 – 27.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.[5]

Interactions

ARHGEF3 has been shown to interact with RHOA[6] and RHOB.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000163947 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021895 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
  6. Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

Further reading


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