ARHGEF9

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[5][6][7]

ARHGEF9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, PEM-2, PEM2, Cdc42 guanine nucleotide exchange factor 9, DEE8
External IDsOMIM: 300429 MGI: 2442233 HomoloGene: 9053 GeneCards: ARHGEF9
Orthologs
SpeciesHumanMouse
Entrez

23229

236915

Ensembl

ENSG00000131089

ENSMUSG00000025656

UniProt

O43307

Q3UTH8

RefSeq (mRNA)

NM_001033329
NM_001290384
NM_001290385

RefSeq (protein)
Location (UCSC)Chr X: 63.63 – 63.81 MbChr X: 94.09 – 94.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][7]

Interactions

ARHGEF9 has been shown to interact with GPHN[8] and SMURF1.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000131089 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025656 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587–93. doi:10.1074/jbc.274.47.33587. PMID 10559246.
  6. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  7. "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9".
  8. Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. doi:10.1038/71096. PMID 10607391. S2CID 24878249.
  9. Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi:10.1515/BC.2008.036. PMID 18208356. S2CID 27505034.

Further reading


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