ARL6IP5

PRA1 family protein 3 is a protein that in humans is encoded by the ARL6IP5 gene.[5][6][7]

ARL6IP5
Identifiers
AliasesARL6IP5, DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx, HSPC127, Yip6b, ADP ribosylation factor like GTPase 6 interacting protein 5
External IDsOMIM: 605709 MGI: 1929501 HomoloGene: 4673 GeneCards: ARL6IP5
Orthologs
SpeciesHumanMouse
Entrez

10550

65106

Ensembl

ENSG00000144746

ENSMUSG00000035199

UniProt

O75915

Q8R5J9

RefSeq (mRNA)

NM_006407

NM_022992

RefSeq (protein)

NP_006398

NP_075368

Location (UCSC)Chr 3: 69.08 – 69.11 MbChr 6: 97.19 – 97.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.[7] The disruption of the mouse gene results in increased neuronal glutathione content, neuroprotection against oxidative stress and a better performance in motor/spatial learning and memory tests than wild-type mice.

Interactions

ARL6IP5 has been shown to interact with SLC1A1.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000144746 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035199 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (Mar 2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. S2CID 4622513.
  6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  7. "Entrez Gene: ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5".

Further reading


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