ARMET

Arginine-rich, mutated in early-stage tumors (ARMET), arginine-rich protein (ARP), or mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein that in humans is encoded by the MANF housekeeping gene.[4][5]

MANF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMANF, ARMET, ARP, arginine-rich, mutated in early-stage tumors, arginine-rich protein, mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte derived neurotrophic factor
External IDsOMIM: 601916 MGI: 1922090 HomoloGene: 4383 GeneCards: MANF
Orthologs
SpeciesHumanMouse
Entrez

7873

74840

Ensembl

ENSG00000145050

ENSMUSG00000032575

UniProt

P55145

Q9CXI5

RefSeq (mRNA)

NM_006010

NM_029103

RefSeq (protein)

NP_006001

n/a

Location (UCSC)Chr 3: 51.39 – 51.39 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a highly conserved protein whose function is known. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000145050 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW (Jun 2003). "MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons". J Mol Neurosci. 20 (2): 173–88. doi:10.1385/JMN:20:2:173. PMID 12794311. S2CID 218459504.
  5. "Entrez Gene: ARMET arginine-rich, mutated in early stage tumors".

Further reading


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