ARNT2

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.[5][6]

ARNT2
Identifiers
AliasesARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDsOMIM: 606036 MGI: 107188 HomoloGene: 7230 GeneCards: ARNT2
Orthologs
SpeciesHumanMouse
Entrez

9915

11864

Ensembl

ENSG00000172379

ENSMUSG00000015709

UniProt

Q9HBZ2

Q61324

RefSeq (mRNA)

NM_014862

NM_007488

RefSeq (protein)

NP_055677
NP_055677.3

NP_031514

Location (UCSC)Chr 15: 80.4 – 80.6 MbChr 7: 83.9 – 84.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000172379 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015709 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
  6. "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2".

Further reading


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