ARPP-19

ARPP19
Identifiers
Aliases	ARPP19, ARPP-16, ARPP-19, ARPP16, ENSAL, cAMP regulated phosphoprotein 19kDa, cAMP regulated phosphoprotein 19
External IDs	OMIM: 605487 MGI: 1891691 HomoloGene: 21318 GeneCards: ARPP19
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	52,569,883 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	75,060,313 bp[2]
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; external globus pallidus; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; optic nerve; ; middle frontal gyrus; ; Brodmann area 10; ; dorsolateral prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; olfactory tubercle; ; yolk sac; ; globus pallidus; ; primary motor cortex; ; nucleus accumbens; ; prefrontal cortex; ; proximal tubule; ; lip; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; potassium channel regulator activity; signaling receptor binding; phosphatase inhibitor activity; protein phosphatase inhibitor activity; protein phosphatase regulator activity;
Cellular component	nucleoplasm; cytoplasm;
Biological process	cell division; positive regulation of glucose import; cell cycle; positive regulation of gluconeogenesis; G2/M transition of mitotic cell cycle; negative regulation of catalytic activity; negative regulation of protein dephosphorylation; mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	10776
	59046
	ENSG00000128989
	ENSMUSG00000007656
	P56211
	P56212
	NM_001306191; NM_001306195; NM_001306196; NM_006628; NM_001330309
	NM_001142655; NM_021548
	NP_001293120; NP_001293124; NP_001293125; NP_001317238; NP_006619
NP_001136127; NP_067523; NP_001344807; NP_001344808; NP_001344809;
	NP_001344810
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-regulated phosphoprotein 19 is a protein that in humans is encoded by the ARPP19 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000128989 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000007656 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC (2001). "ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins". J. Neurochem. 77 (1): 229–38. doi:10.1046/j.1471-4159.2001.t01-1-00191.x. PMID 11279279.
Peyrollier K, Héron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996). "Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins". Biochem. Biophys. Res. Commun. 223 (3): 583–6. doi:10.1006/bbrc.1996.0938. PMID 8687439.
"Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD".

External links

Human ARPP19 genome location and ARPP19 gene details page in the UCSC Genome Browser.

Kim SH, Nairn AC, Cairns N, Lubec G (2001). "Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (61): 263–72. doi:10.1007/978-3-7091-6262-0_21. ISBN 978-3-211-83704-7. PMID 11771749.
Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (1998). "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8387–91. Bibcode:1998PNAS...95.8387H. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.
Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
Horiuchi A, Williams KR, Kurihara T, Nairn AC, Greengard P (1990). "Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19". J. Biol. Chem. 265 (16): 9476–84. doi:10.1016/S0021-9258(19)38874-X. PMID 2160982.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128989 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007656 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11279279-5] Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC (2001). "ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins". J. Neurochem. 77 (1): 229–38. doi:10.1046/j.1471-4159.2001.t01-1-00191.x. PMID 11279279.

[pmid8687439-6] Peyrollier K, Héron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996). "Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins". Biochem. Biophys. Res. Commun. 223 (3): 583–6. doi:10.1006/bbrc.1996.0938. PMID 8687439.

[entrez-7] "Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD".

ARPP-19

References

External links

Further reading