Artesunate/amodiaquine

Artesunate/amodiaquine, sold under the trade name Camoquin among others, is a medication used for the treatment of malaria.[2][3] It is a fixed-dose combination of artesunate and amodiaquine.[2] Specifically it recommended for acute uncomplicated Plasmodium falciparum malaria.[4] It is taken by mouth.[3]

Artesunate/amodiaquine
Combination of
ArtesunateAntimalarial
AmodiaquineAntimalarial
Clinical data
Trade namesCamoquin, others[1]
Other namesASAQ
ATC code
Identifiers
CAS Number
ChemSpider
  • none
UNII
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Common side effects include loss of appetite, nausea, abdominal pain, sleepiness, trouble sleeping, and cough.[5] Safety in pregnancy is not clear; however, the medication may be used if others are not possible.[5] It is believed to be safe for use during breastfeeding.[5] Artesunate and amodiaquine are both antimalarial medication; however, work by different mechanisms.[5]

Artesunate/amodiaquine was commercially launched in 2007.[6] It is on the World Health Organization's List of Essential Medicines.[2] Artesunate/amodiaquine is available as a generic medication.[6] As of 2014 it is not commercially available in the United States or United Kingdom.[1][7]

Medical uses

Early clinical trials showed that a once-a-day dosage was effective.[8] It was subsequently clinically shown to be equally effective as artemether/lumefantrine,[9] although it is likely to be more effective in the field due to its simpler once-a-day dosage compared to artemether/lumefantrine twice-per-day dosage.

Society and culture

Artesunate/amodiaquine was commercially launched in 2007 as an affordable treatment for malaria, devised by DNDi in partnership with Sanofi-Aventis.[6] ASAQ was handed over to the MMV Access and Product Management Team in May 2015.[10]

References
  1. Ainsworth SB (2014). "Amodiaquine with artesunate". Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. John Wiley & Sons. p. 75. ISBN 9781118819517. Archived from the original on 2016-12-20.
  2. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  3. Oyakhirome S, Pötschke M, Schwarz NG, Dörnemann J, Laengin M, Salazar CO, et al. (March 2007). "Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children". Malaria Journal. 6: 29. doi:10.1186/1475-2875-6-29. PMC 1831475. PMID 17352806.
  4. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 187. hdl:10665/44053. ISBN 9789241547659.
  5. "Artesunate Amodiaquine Winthrop" (PDF). WIPO. August 2010. Archived (PDF) from the original on 24 October 2016. Retrieved 12 December 2016.
  6. "New, Once-a-Day Fixed-Dose Combination Against Malaria Now Available – DNDi". www.dndi.org. 1 March 2007. Archived from the original on 20 December 2016. Retrieved 12 December 2016.
  7. Rosenthal PJ, Kamya M (2015). "Malaria". In Goldman L, Schafer AI (eds.). Goldman-Cecil Medicine. Elsevier Health Sciences. p. 2112. ISBN 9780323322850. Archived from the original on 2016-12-20.
  8. Ndiaye JL, Randrianarivelojosia M, Sagara I, Brasseur P, Ndiaye I, Faye B, et al. (June 2009). "Randomized, multicentre assessment of the efficacy and safety of ASAQ--a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria". Malaria Journal. 8: 125. doi:10.1186/1475-2875-8-125. PMC 2698916. PMID 19505304.
  9. Ndiaye JL, Faye B, Gueye A, Tine R, Ndiaye D, Tchania C, et al. (August 2011). "Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial". Malaria Journal. 10: 237. doi:10.1186/1475-2875-10-237. PMC 3171378. PMID 21838909.
  10. "DNDi passes the ball to MMV | Medicines for Malaria Venture". www.mmv.org. 22 May 2015. Retrieved 2020-02-13.
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