ATG4A

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.[5][6]

ATG4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A
External IDsOMIM: 300663 MGI: 2147903 HomoloGene: 70873 GeneCards: ATG4A
Orthologs
SpeciesHumanMouse
Entrez

115201

666468

Ensembl

ENSG00000101844

ENSMUSG00000079418

UniProt

Q8WYN0

Q8C9S8

RefSeq (mRNA)

NM_174875

RefSeq (protein)

NP_777364
NP_001366610
NP_001366611
NP_001366612
NP_001366613

Location (UCSC)Chr X: 108.09 – 108.15 MbChr X: 140.96 – 141.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000101844 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000079418 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
  6. "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".

Further reading


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