ATG4D

The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[5]

ATG4D
Identifiers
AliasesATG4D, APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase, HsAPG4D
External IDsOMIM: 611340 MGI: 2444308 HomoloGene: 13156 GeneCards: ATG4D
Orthologs
SpeciesHumanMouse
Entrez

84971

235040

Ensembl

ENSG00000130734

ENSMUSG00000002820

UniProt

Q86TL0

Q8BGV9

RefSeq (mRNA)

NM_001281504
NM_032885

NM_153583

RefSeq (protein)

NP_001268433
NP_116274

NP_705811

Location (UCSC)Chr 19: 10.54 – 10.55 MbChr 9: 21.18 – 21.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.

This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

  1. GRCh38: Ensembl release 89: ENSG00000130734 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002820 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Autophagy related 4D, cysteine peptidase".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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