Attractin

Attractin is a protein that in humans is encoded by the ATRN gene.[5][6][7]

ATRN
Identifiers
AliasesATRN, DPPT-L, MGCA, attractin
External IDsOMIM: 603130 MGI: 1341628 HomoloGene: 22542 GeneCards: ATRN
Orthologs
SpeciesHumanMouse
Entrez

8455

11990

Ensembl

ENSG00000088812

ENSMUSG00000027312

UniProt

O75882

Q9WU60

RefSeq (mRNA)

NM_001207047
NM_012070
NM_139321
NM_139322
NM_001323332

NM_009730

RefSeq (protein)

NP_001193976
NP_001310261
NP_647537
NP_647538

NP_033860

Location (UCSC)Chr 20: 3.47 – 3.65 MbChr 2: 130.75 – 130.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Attractin is a Group XI C-type lectin.

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000088812 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027312 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF (Oct 1998). "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions". Proc Natl Acad Sci U S A. 95 (19): 11336–41. Bibcode:1998PNAS...9511336D. doi:10.1073/pnas.95.19.11336. PMC 21643. PMID 9736737.
  6. Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF (Apr 1996). "Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells". J Immunol. 156 (5): 1714–21. PMID 8596018.
  7. "Entrez Gene: ATRN attractin".

Further reading


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