AZGP1

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.[5][6]

AZGP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAZGP1, ZA2G, ZAG, alpha-2-glycoprotein 1, zinc-binding
External IDsOMIM: 194460 MGI: 103163 HomoloGene: 915 GeneCards: AZGP1
Orthologs
SpeciesHumanMouse
Entrez

563

12007

Ensembl

ENSG00000160862

ENSMUSG00000037053

UniProt

P25311

Q64726

RefSeq (mRNA)

NM_001185

NM_013478

RefSeq (protein)

NP_001176

NP_038506

Location (UCSC)Chr 7: 99.97 – 99.98 MbChr 5: 137.98 – 137.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.[7] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[7] Zinc-alpha-2-glycoprotein levels also rise with onset of diabetes 2, which accounts for weight loss thereafter.


References

  1. GRCh38: Ensembl release 89: ENSG00000160862 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037053 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID 2049092.
  6. "Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding".
  7. Vanni, H; Kazeros, A; Wang, R; Harvey, BG; Ferris, B; De, BP; Carolan, BJ; Hübner, RH; et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest. 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC 2679098. PMID 19188554.

Further reading


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