Acetoacetate—CoA ligase

In enzymology, an acetoacetate—CoA ligase (EC 6.2.1.16) is an enzyme that catalyzes the chemical reaction

ATP + acetoacetate + CoA AMP + diphosphate + acetoacetyl-CoA
Acetoacetate—CoA ligase
Identifiers
EC no.6.2.1.16
CAS no.39394-62-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.

References

    • Fukui T, Ito M, Tomita K (1982). "Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M". Eur. J. Biochem. 127 (2): 423–8. doi:10.1111/j.1432-1033.1982.tb06889.x. PMID 7140777.


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