Acridone alkaloids

Acridone alkaloids are natural products derived from acridone.[1]

Acridone, parent compound of the acridone alkaloids.
Wine rue (Ruta graveolens)

Occurrence

Acridone alkaloids are found in bark, wood, leaves and roots of rue plants,[1] especially in roots and suspension cultures of rue.[2]

Examples

This group is named after the acridone. Further members are acronycin, melicopicine and rutacridone, among others:[1][3]

  • Acronycin
    Acronycin
  • Melicopicine
    Melicopicine
  • Rutacridon
    Rutacridon

Properties

Many acridone alkaloids are methylated on the nitrogen atom and also have two oxygen functional groups, which can be free, alkylated or incorporated into rings. Acridone alkaloids show a blue-green fluorescence so that they can be detected with UV light. Some alkaloids of this group are effective against malaria pathogens. Furthermore, acronycin inhibits cell division.[2]

References
  1. Entry on Acridone. at: Römpp Online. Georg Thieme Verlag, retrieved 21 April 2020.
  2. R. Hänsel, O.Sticher (2007), Pharmakognosie Phytopharmazie (in German) (8 ed.), Heidelberg: Springer Medizin Verlag, pp. 101,1326, ISBN 9783540265085
  3. "Acridone alkaloid biosynthesis". Archived from the original on 12 June 2020. Retrieved 22 April 2020.
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