Alberto Priori

Alberto Priori is an Italian neurologist, academic, and author. He is a Professor of Neurology at the University of Milan, Director of Neurology 1 Unit at San Paolo Hospital,[1] and the Founder and Coordinator of Aldo Ravelli Center (Coordinated Research Center) of the University of Milan. He also serves as President of the Neurophysiopatology Tecniques Course, and Professor of Postgraduate Schools - Medicine, Healthcare, Dental Medicine at the same University.[2]

Alberto Priori
Born (1962-11-19) November 19, 1962
Turin, Italy
NationalityItalian
Occupation(s)Neurologist, academic, and author
Academic background
EducationDegree in Medicine and Surgery
Specialization in Neurology
Doctor of Philosophy (PhD)
Alma materUniversity of Rome “La Sapienza”
Academic work
InstitutionsUniversity of Milan

Priori is internationally recognized for his wide-ranging research on the pathophysiological mechanisms that underlie diseases of the brain and of the peripheral nervous system. He developed innovative technologies for the treatment of neuropsychiatric disorders, and has also pioneered the implementation of several neuromodulation techniques.[3] In 2008, he founded the Newronika SpA a spin-off company of the University of Milan and Fondazione IRCCS Ca’ Granda in Milan, Italy. The company is dedicated to the development of neurotechnological devices for the treatment of neurological disorders.[4]

Early life and education

Priori was born in Turin, Italy in 1962. He studied at the University of Rome "La Sapienza", and got his Degree in Medicine and Surgery in 1987, specialization in Neurology in 1991, and a Doctoral degree in 1995. His dissertation on the non-invasive study of the inhibitory mechanisms in the human cerebral cortex, was supervised by Alfredo Berardelli and Mario Manfredi.[5] From 1997 till 1998, Priori was a Postdoctoral fellow at the University of Rome "La Sapienza."[2]

Career

Priori began his career in 1990, with an appointment as a Research Registrar of Human Movement and Balance Unit dell’ Institute of Neurology at the University of London in the period 1989-1991. From 1992 till 1998, he was appointed as an Attending physician in the Department of Neurology of Ospedale Mellino Mellini di Chiari (BS). Following this, he joined Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico of Milan, and served there as a Neurologist from 1998 till 2015, and as a Director from 2008 till 2015. During this time period, he also held a concurrent appointment as an Army Medical Corps Captain.[6]

Research

Priori's research spans the fields of clinical and experimental neurosciences with particular attention on movement disorders and their pathophysiology, clinical and experimental neurophysiology,[7][8] behavioral neurology, and neuromodulation. With collaboration of clinical neuroscientists, he works extensively to develop technologies for the treatment of neuropsychiatric disorders. He has published over 300 papers.[9] For his research in the field, he has also received several competitive research grants provided by national and international institutes.[10]

Adaptive deep brain stimulation (aDBS)

Priori led the group who developed, in 2004, and eventually patented, the adaptive Deep Brain Stimulation technique. This technology has been licensed to Newonika.[11] Along with discussing the efficacy of deep brain stimulation (DBS) in terms of treating neurological disorders, Priori has presented a review on the evidences regarding the advantages of neurosignal-controlled aDBS that uses local field potentials (LFPs) as a control variable. His research highlighted how DBS systems automatically adjust stimulation by analyzing the individual patient's condition, and then improve control over parkinsonian disturbances.[12] In 2017, he presented a report on the possible pathways for the clinical translation of aDBS with its benefits, limitations and unsolved issues.[13] He also developed and validated an external portable aDBS system prototype with an application to promote clinical investigations in Parkinson's Disease.[14] Moreover, he discussed the implications of aDBS in the context of providing effective treatment method for the management of clinical fluctuations,[15] as well as controlling levodopa‐induced side effects in Parkinsonian patients.[16]

In 2021, he conducted a comparative analysis of the impacts occurred on motor symptoms as a result of conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson's Disease.[17] He also presented an implantable closed-loop clinical neural interface, and described its first application in Parkinson's disease.[18]

Low intensity transcranial electrical stimulation (TES)

Priori is the first to describe a technique now known as transcranial direct current stimulation (tDCS). Lately, he has implemented this technique by developing the methodology for stimulating with non-invasive DC, the cerebellum and the spinal cord. In 2008, he provided the state of the art for tDCS, while highlighting the applications of tDCS in terms of inducing beneficial effects in brain disorders. He regarded brain stimulation with weak direct currents as a promising tool in the context of human neuroscience and neurobehavioral research.[19] In a later study, he presented a comprehensive review to discuss the key challenges that occur in the process of conducting clinical research with transcranial direct current stimulation (tDCS).[20] Having discussed the challenges, he described the evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS),[21][22] and low intensity transcranial electric stimulation (TES).[23]

Neuropsychiatric impact of COVID-19 pandemic

Priori focused his study to explore the long-lasting cognitive abnormalities that can occur in the COVID-19 patients in the months after hospital discharge.[24][25] In 2020, he provided justifications regarding "The international European Academy of Neurology survey on neurological symptoms in patients with COVID-19 infection." He is of the view that the survey serves to set up a prospective registry to better capture the prevalence of patients with neuro COVID-19, neurological disease characteristics and the contribution of neurological manifestations to outcome.[26] While discussing the psychological implications of the first outbreak of COVID-19 in the context of Italy, he offered several ways to minimize the impact in daily life activities, such as sexuality and nutrition.[27][28]

Bibliography

Monographs
  • Neurology of Covid-19 (2021) ISBN 979-12-80325-37-2
  • Durante un'epidemia. Aspetti psicologici e psicopatologici legati alla pandemia di Covid-19 (2021) ISBN 978-88-590-2541-2

Selected articles
  • Priori, A., Berardelli, A., Inghilleri, M., Accornero, N., & Manfredi, M. (1994). Motor cortical inhibition and the dopaminergic system: pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism. Brain, 117(2), 317-323.
  • Priori, A., Berardelli, A., Rona, S., Accornero, N., & Manfredi, M. (1998). Polarization of the human motor cortex through the scalp. Neuroreport, 9(10), 2257-2260.
  • Priori, A. (2003). Brain polarization in humans: a reappraisal of an old tool for prolonged non-invasive modulation of brain excitability. Clinical neurophysiology, 114(4), 589-595.
  • Priori, A., & Lefaucheur, J. P. (2007). Chronic epidural motor cortical stimulation for movement disorders. The Lancet Neurology, 6(3), 279-286.
  • Priori, A., Foffani, G., Rossi, L., & Marceglia, S. (2013). Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations. Experimental neurology, 245, 77-86.

References
  1. Talan, Jamie (March 27, 2020). "COVID-19: Neurologists in Italy to Colleagues in US: Look for Poorly-Defined Neurologic Conditions in Patients with the Coronavirus". Neurology Today – via journals.lww.com.
  2. "Priori Alberto - Università degli Studi di Milano".
  3. "Alberto Priori – ResearchGate Profile".
  4. "2019-11-12 - Alberto Priori". NIMET: Nanoscience Institute for Medical & Engineering Technology.
  5. "Alberto Priori – IEEE Xplore".
  6. "Prof. Alberto Priori". www.asst-santipaolocarlo.it.
  7. Priori, Alberto; Berardelli, Alfredo; Rona, Sabine; Accornero, Neri; Manfredi, Mario (July 13, 1998). "Polarization of the human motor cortex through the scalp". NeuroReport. 9 (10): 2257–2260. doi:10.1097/00001756-199807130-00020. PMID 9694210. S2CID 36460106 – via journals.lww.com.
  8. Ferbert, A; Priori, A; Rothwell, J C; Day, B L; Colebatch, J G; Marsden, C D (July 1, 1992). "Interhemispheric inhibition of the human motor cortex". The Journal of Physiology. 453 (1): 525–546. doi:10.1113/jphysiol.1992.sp019243. PMC 1175572. PMID 1464843.
  9. "Alberto Priori". scholar.google.it.
  10. "Loop | Alberto Priori". loop.frontiersin.org.
  11. "Newronika Interview".
  12. Priori, Alberto; Foffani, Guglielmo; Rossi, Lorenzo; Marceglia, Sara (July 1, 2013). "Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations". Experimental Neurology. 245: 77–86. doi:10.1016/j.expneurol.2012.09.013. PMID 23022916. S2CID 37560257 – via ScienceDirect.
  13. Arlotti, Mattia; Rosa, Manuela; Marceglia, Sara; Barbieri, Sergio; Priori, Alberto (July 1, 2016). "The adaptive deep brain stimulation challenge". Parkinsonism & Related Disorders. 28: 12–17. doi:10.1016/j.parkreldis.2016.03.020. hdl:11585/570018. PMID 27079257 – via ScienceDirect.
  14. Arlotti, Mattia; Rossi, Lorenzo; Rosa, Manuela; Marceglia, Sara; Priori, Alberto (May 1, 2016). "An external portable device for adaptive deep brain stimulation (aDBS) clinical research in advanced Parkinson's Disease". Medical Engineering & Physics. 38 (5): 498–505. doi:10.1016/j.medengphy.2016.02.007. hdl:11585/570013. PMID 27029510 – via ScienceDirect.
  15. Arlotti, Mattia; Marceglia, Sara; Foffani, Guglielmo; Volkmann, Jens; Lozano, Andres M.; Moro, Elena; Cogiamanian, Filippo; Prenassi, Marco; Bocci, Tommaso; Cortese, Francesca; Rampini, Paolo; Barbieri, Sergio; Priori, Alberto (March 13, 2018). "Eight-hours adaptive deep brain stimulation in patients with Parkinson disease". Neurology. 90 (11): e971–e976. doi:10.1212/WNL.0000000000005121. PMC 5858949. PMID 29444973 – via n.neurology.org.
  16. Rosa, M.; Arlotti, M.; Marceglia, S.; Cogiamanian, F.; Ardolino, G.; Fonzo, A. D.; Lopiano, L.; Scelzo, E.; Merola, A.; Locatelli, M.; Rampini, P. M.; Priori, A. (2017). "Adaptive deep brain stimulation controls levodopa‐induced side effects in Parkinsonian patients - PMC". Movement Disorders. 32 (4): 628–629. doi:10.1002/mds.26953. PMC 5412843. PMID 28211585.
  17. Bocci, T.; Prenassi, M.; Arlotti, M.; Cogiamanian, F. M.; Borellini, L.; Moro, E.; Lozano, A. M.; Volkmann, J.; Barbieri, S.; Priori, A.; Marceglia, S. (2021). "Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease - PMC". npj Parkinson's Disease. 7 (1): 88. doi:10.1038/s41531-021-00229-z. PMC 8478873. PMID 34584095.
  18. Arlotti, Mattia; Colombo, Matteo; Bonfanti, Andrea; Mandat, Tomasz; Lanotte, Michele Maria; Pirola, Elena; Borellini, Linda; Rampini, Paolo; Eleopra, Roberto; Rinaldo, Sara; Romito, Luigi; Janssen, Marcus L. F.; Priori, Alberto; Marceglia, Sara (August 24, 2021). "A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson's Disease". Frontiers in Neuroscience. 15: 763235. doi:10.3389/fnins.2021.763235. PMC 8689059. PMID 34949982.
  19. Nitsche, Michael A.; Cohen, Leonardo G.; Wassermann, Eric M.; Priori, Alberto; Lang, Nicolas; Antal, Andrea; Paulus, Walter; Hummel, Friedhelm; Boggio, Paulo S.; Fregni, Felipe; Pascual-Leone, Alvaro (July 1, 2008). "Transcranial direct current stimulation: State of the art 2008". Brain Stimulation. 1 (3): 206–223. doi:10.1016/j.brs.2008.06.004. PMID 20633386. S2CID 16352598 – via ScienceDirect.
  20. Brunoni, Andre Russowsky; Nitsche, Michael A.; Bolognini, Nadia; Bikson, Marom; Wagner, Tim; Merabet, Lotfi; Edwards, Dylan J.; Valero-Cabre, Antoni; Rotenberg, Alexander; Pascual-Leone, Alvaro; Ferrucci, Roberta; Priori, Alberto; Boggio, Paulo Sergio; Fregni, Felipe (July 1, 2012). "Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions". Brain Stimulation. 5 (3): 175–195. doi:10.1016/j.brs.2011.03.002. PMC 3270156. PMID 22037126.
  21. Lefaucheur, Jean-Pascal; Antal, Andrea; Ayache, Samar S.; Benninger, David H.; Brunelin, Jérôme; Cogiamanian, Filippo; Cotelli, Maria; De Ridder, Dirk; Ferrucci, Roberta; Langguth, Berthold; Marangolo, Paola; Mylius, Veit; Nitsche, Michael A.; Padberg, Frank; Palm, Ulrich; Poulet, Emmanuel; Priori, Alberto; Rossi, Simone; Schecklmann, Martin; Vanneste, Sven; Ziemann, Ulf; Garcia-Larrea, Luis; Paulus, Walter (January 1, 2017). "Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)". Clinical Neurophysiology. 128 (1): 56–92. doi:10.1016/j.clinph.2016.10.087. hdl:10067/1420300151162165141. PMID 27866120. S2CID 4837447 – via ScienceDirect.
  22. Woods, A. J.; Antal, A.; Bikson, M.; Boggio, P. S.; Brunoni, A. R.; Celnik, P.; Cohen, L. G.; Fregni, F.; Herrmann, C. S.; Kappenman, E. S.; Knotkova, H.; Liebetanz, D.; Miniussi, C.; Miranda, P. C.; Paulus, W.; Priori, A.; Reato, D.; Stagg, C.; Wenderoth, N.; Nitsche, M. A. (February 1, 2016). "A technical guide to tDCS, and related non-invasive brain stimulation tools". Clinical Neurophysiology. 127 (2): 1031–1048. doi:10.1016/j.clinph.2015.11.012. PMC 4747791. PMID 26652115.
  23. Antal, A.; Alekseichuk, I.; Bikson, M.; Brockmöller, J.; Brunoni, A. R.; Chen, R.; Cohen, L. G.; Dowthwaite, G.; Ellrich, J.; Flöel, A.; Fregni, F.; George, M. S.; Hamilton, R.; Haueisen, J.; Herrmann, C. S.; Hummel, F. C.; Lefaucheur, J. P.; Liebetanz, D.; Loo, C. K.; McCaig, C. D.; Miniussi, C.; Miranda, P. C.; Moliadze, V.; Nitsche, M. A.; Nowak, R.; Padberg, F.; Pascual-Leone, A.; Poppendieck, W.; Priori, A.; Rossi, S.; Rossini, P. M.; Rothwell, J.; Rueger, M. A.; Ruffini, G.; Schellhorn, K.; Siebner, H. R.; Ugawa, Y.; Wexler, A.; Ziemann, U.; Hallett, M.; Paulus, W. (September 1, 2017). "Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines". Clinical Neurophysiology. 128 (9): 1774–1809. doi:10.1016/j.clinph.2017.06.001. PMC 5985830. PMID 28709880.
  24. Ferrucci, Roberta; Dini, Michelangelo; Groppo, Elisabetta; Rosci, Chiara; Reitano, Maria Rita; Bai, Francesca; Poletti, Barbara; Brugnera, Agostino; Silani, Vincenzo; D’Arminio Monforte, Antonella; Priori, Alberto (February 24, 2021). "Long-Lasting Cognitive Abnormalities after COVID-19". Brain Sciences. 11 (2): 235. doi:10.3390/brainsci11020235. PMC 7917789. PMID 33668456.
  25. "Neurology of Covid-19".
  26. Moro, E.; Priori, A.; Beghi, E.; Helbok, R.; Campiglio, L.; Bassetti, C. L.; Bianchi, E.; Maia, L. F.; Ozturk, S.; Cavallieri, F.; Zedde, M.; Sellner, J.; Bereczki, D.; Rakusa, M.; Di Liberto, G.; Sauerbier, A.; Pisani, A.; MacErollo, A.; Soffietti, R.; Taba, P.; Crean, M.; Twardzik, A.; Oreja‐Guevara, C.; Bodini, B.; Jenkins, T. M.; Oertzen, T. J.; EAN core COVID-19 Task Force (September 24, 2020). "The international European Academy of Neurology survey on neurological symptoms in patients with COVID‐19 infection". European Journal of Neurology. 27 (9): 1727–1737. doi:10.1111/ene.14407. PMC 7323212. PMID 32558002.
  27. Roberta, Ferrucci; Alberto, Averna; Daniela, Marino; Rita, Reitano, Maria; Fabiana, Ruggiero; Francesca, Mameli; Michelangelo, Dini; Barbara, Poletti; Sergio, Barbieri; Alberto, Priori; Gabriella, Pravettoni (August 24, 2020). "Psychological Impact During the First Outbreak of COVID-19 in Italy". Frontiers in Psychiatry. 11: 559266. doi:10.3389/fpsyt.2020.559266. PMC 7667038. PMID 33240119.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  28. Ferrarese, Carlo; Silani, Vincenzo; Priori, Alberto; Galimberti, Stefania; Agostoni, Elio; Monaco, Salvatore; Padovani, Alessandro; Tedeschi, Gioacchino; Italian Society of Neurology (SIN) (June 1, 2020). "An Italian multicenter retrospective-prospective observational study on neurological manifestations of COVID-19 (NEUROCOVID)". Neurological Sciences. 41 (6): 1355–1359. doi:10.1007/s10072-020-04450-1. PMC 7235538. PMID 32430621 – via Springer Link.
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