Alexandre Loupy

Alexandre Loupy (born 21 July 1977 in Saint-Denis de la Réunion) is a French nephrologist, a university professor and hospital practitioner at the Necker Hospital of the Assistance Publique - Hôpitaux de Paris, in the kidney transplant department.[1] He is known for his discoveries on the topic of graft rejection.[2],[3],[4] Its approach proposing innovative methodological tools has led to a better understanding but has also led to important changes in the international classification of graft rejection.[5],[6] These discoveries allow to improve the performance of clinical trials and to consider new therapeutic innovations in transplantation.[7]

Alexandre Loupy
Born21 July 1977
Saint Denis de la Réunion, France
Awards
  • French National Academy of Medicine prize (2018),
  • AST Clinical Science Investigator Award (2017)
Scientific career
FieldsMedicine, Nephrology, Transplantation, Epidemiology, Biostatistics
Institutions
Academic advisorsChristophe Legendre

Biography

Alexandre Loupy was born in Saint-Denis de la Réunion, France, on 21 July 1977. He is the son of Jack Loupy, company manager and travel agency director, and Françoise Loupy, pharmacist.[8] He spent his entire schooling on Reunion Island before entering medical school in Bordeaux, France.[9]

In 2002, he joined the Paris Hospitals and, in 2008, obtained his Diploma of Specialized Studies in Nephrology.[10] In 2011, he obtained his PhD in Basic Sciences, and in 2014 obtained a PhD in Biostatistics.[11]

Loupy defended a doctoral thesis in medicine in 2008. He also defended two academic theses: in cell biology on the "Role of Calcium/polycation-sensing receptor >> CaSR in the regulation of blood calcium levels independently of parathyroid hormone" at the Pierre and Marie Curie University under the supervision of Pascal Houillier in 2011,[12] and in epidemiology on the "Prognostic role of anti-HLA antibodies in kidney transplantation: population-based approaches" at the Paris Descartes University under the direction of Xavier Jouven in 2014.[12]

He is now a university professor and hospital practitioner at the Necker Hospital of the Assistance Publique - Hôpitaux de Paris, in the kidney transplant department.[1]

Scientific work

Alexandre Loupy's work has focused on allograft rejection and the relationship between the presence of antibodies and the progressive destruction of the graft. With the Paris Transplant Group, the Inserm research team which he established in 2017,[11] he developed a population-based approach to organ transplantation using methodological tools based on classical statistical techniques but also on automated learning, machine learning and artificial intelligence.

With his research team, Loupy is developing an algorithm, called integrative Box or iBox, which predicts the short, medium and long term fate of the graft.[7] This tool allows to finely characterize graft rejection by analyzing the expression of genes in the kidney, heart or lung graft.

More recently, his work has been extended to the optimization of organ allocation and their better use around the world.[13] The results of his research led to recommendations for the use of organ from older donors for transplantation in the United States in 2019.[14],[15] He is also piloting large epidemiological studies on the consequences of the COVID-19 pandemic on organ transplantation in 12 countries.[16] His team has also been mobilized to evaluate the methodological and scientific quality of the studies on COVID-19.[17]

Publications

Loupy is the author of many major publications including :

  • "System for Predicting the Risk of Allograft Loss in Renal Transplant Patients: International Derivation and Validation Study" published in BMJ magazine in 2019.[7]

He is also the lead author of numerous major publications in leading medical journals such as The New England Journal of Medicine, The Lancet, the JAMA, the BMJ, Annals of Internal Medicine, PLOS Medicine, Journal of Clinical Investigation, Circulation and Circulation Research. and more specialized peer-reviewed journals such as Kidney International, Journal of the American Society of Nephrology and American Journal of Transplantation.

His work is regularly featured in the French and international media such as L'Obs,[18] CNN[14] and NBC.

Awards and honors

In 2018, Alexandre Loupy was rewarded by the French National Academy of Medicine for his work on kidney transplantation, anti-HLA graft rejection and the identification of associated biomarkers.[19]

He is also a recipient of the American Society of Transplantation,[20] the StrongTogether PRO Award,[21] and the 2020 recipient of the Paul I. Terasaki Clinical Science Award., was established by the American Society for Histocompatibility and Immunogenetics in honour of Paul Terasaki.[22]

The European Society of Transplantation designation his Paris Transplant Group as the most scientifically productive team in the transplantation field 4 years in a row.[23]

He has been Editor of the American Journal of Transplantation since 2017.[24]

Loupy is an expert for the Food and Drug Administration[25] and has been the Scientific Director of the International Classification of Rejection since 2015.[5],[26]

References
  1. "Avancées majeures dans le diagnostic et le traitement du rejet d'allogreffe". www.aphp.fr (in French). Retrieved 2020-04-29.
  2. Loupy, Alexandre; Lefaucheur, Carmen; Vernerey, Dewi; Prugger, Christof; van Huyen, Jean-Paul Duong; Mooney, Nuala; Suberbielle, Caroline; Frémeaux-Bacchi, Véronique; Méjean, Arnaud; Desgrandchamps, François; Anglicheau, Dany (2013-09-26). "Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival". New England Journal of Medicine. 369 (13): 1215–1226. doi:10.1056/NEJMoa1302506. ISSN 0028-4793. PMID 24066742.
  3. Loupy, Alexandre; Lefaucheur, Carmen (2018-09-20). Ingelfinger, Julie R. (ed.). "Antibody-Mediated Rejection of Solid-Organ Allografts". New England Journal of Medicine. 379 (12): 1150–1160. doi:10.1056/NEJMra1802677. ISSN 0028-4793. PMID 30231232. S2CID 52305362.
  4. Lefaucheur, Carmen; Loupy, Alexandre; Vernerey, Dewi; Duong-Van-Huyen, Jean-Paul; Suberbielle, Caroline; Anglicheau, Dany; Vérine, Jérôme; Beuscart, Thibaut; Nochy, Dominique; Bruneval, Patrick; Charron, Dominique (January 2013). "Antibody-mediated vascular rejection of kidney allografts: a population-based study". The Lancet. 381 (9863): 313–319. doi:10.1016/S0140-6736(12)61265-3. PMID 23182298. S2CID 29447718.
  5. Loupy, A.; Haas, M.; Solez, K.; Racusen, L.; Glotz, D.; Seron, D.; Nankivell, B. J.; Colvin, R. B.; Afrouzian, M.; Akalin, E.; Alachkar, N. (January 2017). "The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology". American Journal of Transplantation. 17 (1): 28–41. doi:10.1111/ajt.14107. PMC 5363228. PMID 27862883.
  6. Haas, M.; Loupy, A.; Lefaucheur, C.; Roufosse, C.; Glotz, D.; Seron, D.; Nankivell, B. J.; Halloran, P. F.; Colvin, R. B.; Akalin, Enver; Alachkar, N. (February 2018). "The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials". American Journal of Transplantation. 18 (2): 293–307. doi:10.1111/ajt.14625. PMC 5817248. PMID 29243394.
  7. Loupy, Alexandre; Aubert, Olivier; Orandi, Babak J; Naesens, Maarten; Bouatou, Yassine; Raynaud, Marc; Divard, Gillian; Jackson, Annette M; Viglietti, Denis; Giral, Magali; Kamar, Nassim (2019-09-17). "Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study". BMJ. 366: l4923. doi:10.1136/bmj.l4923. ISSN 0959-8138. PMC 6746192. PMID 31530561.
  8. fxg. "Dr Alexandre Loupy, de la Reunion au New England Journal of medecine [sic]". le blog fxgpariscaraibe (in French). Retrieved 2020-04-29.
  9. OK. "Alexandre Loupy primé par l'American Society of Transplantation". Clicanoo.re (in French). Retrieved 2020-04-29.
  10. "Alexandre Loupy, Néphrologue réunionnais à Necker, primé par la Société américaine de transplantation - Toute l'actualité des Outre-mer à 360°". Toute l'actualité des Outre-mer à 360° (in French). Retrieved 2020-04-29.
  11. "Alexandre Loupy". PTG. Retrieved 2020-04-29.
  12. Méthodologie statistique pour la prédiction du risque et la construction de score pronostique en transplantation rénale et en oncologie : une pierre angulaire de la médecine de précision (Thesis).
  13. Aubert, Olivier; Reese, Peter P.; Audry, Benoit; Bouatou, Yassine; Raynaud, Marc; Viglietti, Denis; Legendre, Christophe; Glotz, Denis; Empana, Jean-Phillipe; Jouven, Xavier; Lefaucheur, Carmen (2019-10-01). "Disparities in Acceptance of Deceased Donor Kidneys Between the United States and France and Estimated Effects of Increased US Acceptance". JAMA Internal Medicine. 179 (10): 1365–1374. doi:10.1001/jamainternmed.2019.2322. ISSN 2168-6106. PMC 6714020. PMID 31449299.
  14. Jen Christensen (18 December 2019). "Trump administration seeks to make more kidneys available for transplants". CNN. Retrieved 2020-04-29.
  15. Pearson, Jeffrey; Turenne, Marc; Leichtman, Alan (November 2019). "The Executive Order on Kidney Care: An Opportunity to Improve Outcomes for Individuals With Kidney Disease". Kidney International Reports. 4 (11): 1519–1522. doi:10.1016/j.ekir.2019.09.011. ISSN 2468-0249. PMC 6933461. PMID 31889730.
  16. Loupy, Alexandre; Aubert, Olivier; Reese, Peter P.; Bastien, Olivier; Bayer, Florian; Jacquelinet, Christian (2020-05-23). "Organ procurement and transplantation during the COVID-19 pandemic". The Lancet. 395 (10237): e95–e96. doi:10.1016/S0140-6736(20)31040-0. ISSN 0140-6736. PMC 7213957. PMID 32407668.
  17. Raynaud, Marc; Zhang, Huanxi; Louis, Kevin; Goutaudier, Valentin; Wang, Jiali; Dubourg, Quentin; Wei, Yongcheng; Demir, Zeynep; Debiais, Charlotte; Aubert, Olivier; Bouatou, Yassine (December 2021). "COVID-19-related medical research: a meta-research and critical appraisal". BMC Medical Research Methodology. 21 (1): 1. doi:10.1186/s12874-020-01190-w. ISSN 1471-2288. PMC 7780085. PMID 33397292.
  18. "La France greffe des reins plus vieux qu'aux Etats-Unis, et sauve des vies". L'Obs (in French). 26 August 2019. Retrieved 2020-04-29.
  19. "Lauréats 2018". Académie nationale de médecine | Une institution dans son temps (in French). 2018-06-26. Retrieved 2020-04-29.
  20. "2017 AST Achievement Award Recipients". American Society of Transplantation. 2017-05-25. Retrieved 2020-04-29.
  21. Menu, Cécile. "L'intelligence artificielle au service des transplantés rénaux". M-Soigner (in French). Retrieved 2020-04-29.
  22. "Awards - American Society for Histocompatibility and Immunogenetics". www.ashi-hla.org. Retrieved 2020-10-09.
  23. "PTG awarded the ESOT StrongeR Together Pro Award". PTG. Retrieved 2020-04-29.
  24. "American Journal of Transplantation". Wiley Online Library. doi:10.1111/(ISSN)1600-6143. Retrieved 2020-04-29.
  25. "MEETING OF EVIDENCE-BASED TREATMENT DECISIONS IN TRANSPLANTATION, THE RIGHT DOSE & REGIMEN FOR THE RIGHT PATIENT/INDIVIDUALIZED TREATMENT". Food and Drug Administration. 27 September 2018. Archived from the original on 2021-03-11. Retrieved 29 April 2020.
  26. "About The Banff Foundation for Allograft Pathology". BANFF. Retrieved 2020-04-29.
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