Ali Khademhosseini

Ali Khademhosseini (Persian: علی خادم‌حسینی, born October 30, 1975, Tehran, Iran) is the CEO of the Terasaki Institute, non-profit research organization in Los Angeles, and Omeat Inc., a cultivated-meat startup. Before taking his current CEO roles, he spent one year at Amazon Inc.[1] Prior to that he was the Levi Knight chair and professor at the University of California-Los Angeles where he held a multi-departmental professorship in Bioengineering, Radiology, Chemical, and Biomolecular Engineering as well as the Director of Center for Minimally Invasive Therapeutics (C-MIT).[2] From 2005 to 2017, he was a professor at Harvard Medical School, and the Wyss Institute for Biologically Inspired Engineering.

Ali Khademhosseini
Khademhosseini in 2022
Born (1975-10-30) October 30, 1975
Tehran, Iran
CitizenshipIranian, Canadian, American
Alma mater
AwardsMustafa Prize, PECASE
Scientific career
Fields
Institutions
Theses
Doctoral advisorRobert S. Langer
Other academic advisorsPeter Zandstra
Notable studentsAkhilesh K. Gaharwar Amir Manbachi

He is an academic entrepreneur who has made contributions in biomaterials and regenerative medicine, particular for developing hydrogels for tissue engineering and bioprinting. He has started multiple companies, including Obsidio Inc. (sold to Boston Scientific) and Omeat Inc.[3][4]

His studies have been cited over 115,000 times (H index = 175).[5] Every year since 2014 he has been selected by Thomson Reuters as one of the World's Most Influential Minds.[6] By the number of citations, he is the most cited author of in various journals in the field of biomaterials like Biomaterials, Advanced Healthcare Materials, Biofabrication, Tissue Engineering - Part B: Reviews.[7]

Background and personal life

Khademhosseini was born in Tehran, Iran, and grew up in Toronto, Canada. He received his Ph.D. in bioengineering from MIT under the supervision of Robert S. Langer (2005), and MASc (2001) and BASc (1999) degrees from the University of Toronto both in chemical engineering.[8]

Accomplishments

Dr. Khademhosseini is a leader in developing ‘personalized’ solutions that utilize micro- and nanoscale technologies to enable a range of therapies for organ failure, cardiovascular disease, and cancer.[9][10] For example, he has developed numerous techniques for controlling the behavior of patient-derived cells to engineer artificial tissues and cell-based therapies.[11] He is also developing ‘organ-on-a-chip’ systems that mimic human physiology and pathology to enable patient-specific evaluation of drug candidates. In addition, his laboratory is utilizing biofabrication to form vascularized tissues with appropriate microarchitectures and regulate stem cell differentiation in microengineered environments. He has also developed various high-performance biomaterials for numerous applications in tissue engineering and regenerative medicine. For example, he has developed and popularized gelatin methacryloyl (GelMA) which has become one of the main materials for 3D bioprinting industry.[12] He also developed electrically conductive, tunable hydrogels by mixing GelMA with nanomaterials, including gold nanoparticles and carbon-based nanomaterials.[13][14][15][16] He has demonstrated the use of GelMA-based materials for tissue engineering and other clinical applications such as sealants and hemostats.[17][18]

He has also made advancements in new 3D bioprinters.[19] In one example, he has developed an innovative multi-nozzle, multi-material bioprinter.[20] In another example, he has engineered stereolithography-based bioprinters.[21] He has developed different bioinks for various tissue engineering applications.[22][23]

Another area of focus has been on building multi-organ on-a-chip systems with integrated in-line sensors.[24] Such devices are finding use in the next generation of organs on a chip systems. His early work in electrochemical biosensors with regeneration ability and microfluidic physical sensors allowed in-line monitoring of organs-on-a-chip platforms.[25][26][27] He was also one of the pioneers of smart patches for chronic wound healing, where both sensing the wound and the rapid drug intervention was conducted using the same device.[28] He has also made key contributions to vascularizing thick tissues with technologies including sacrificial molding, bioprinting, and microengineering.[29][30][31] [32]

He has edited multiple books/journal special issues and is an author on >700 peer-reviewed journal articles, editorials, review papers, >70 book chapters/edited books, and >50 patent/disclosure applications. His work has been published in leading journals and routinely highlighted in international media.[33]

Translational efforts

Khademhosseini is an academic entrepreneur who has started multiple companies to translate the findings of his research into products. He combined silica nanoparticles with gelatin to engineer shear-thinning materials for the embolization of blood vessels in the peripheral vasculature. He then co-founded Obsidio Medical to pursue clinical applications of this breakthrough. The technology was approved by U.S. Food and Drug Administration, and Obsidio Medical was acquired by Boston Scientific in August 2022.[34][35][36]

He also founded Omeat Inc., aiming to produce cultivated meat in a scalable and affordable manner.[37][38] Omeat is a vertically integrated meat company that also produces humane and cost effective fetal bovine serum replacement.[39]

Awards and honors

Dr. Khademhosseini's interdisciplinary research has been recognized over 70 major national and international awards. He is a recipient of the 2011 Presidential Early Career Award for Scientists and Engineers (PECASE) by President Barack Obama, the highest honor given by the US government for early-career investigators.[40] Khademhosseini is a recipient of the Massachusetts Institute of Technology Outstanding Undergraduate mentor award. In 2007, he was named a TR35 recipient by the MIT Technology Review magazine as one of the world's top young innovators.[41] In addition, he has received the young investigator awards of the Society for Biomaterials and the Tissue Engineering and Regenerative Medicine International Society. He has also received the American Chemical Society's Viktor K. Lamer award and the Unilever award and has been recognized by major governmental Awards including the NSF Career award and the Office of Naval Research Young Investigator award.

In 2011, he received the Pioneers of Miniaturization Prize from the Royal Society of Chemistry for his contribution to microscale tissue engineering and microfluidics. In 2016, he received the Sr. Scientist Award of Tissue Engineering and Regenerative Medicine Society-Americas (TERMIS-AM) and in 2017 he received the Clemson Award of the Society for Biomaterials. In 2019, he received the Mustafa Prize, for his work on microfabricated hydrogel for biomedical applications.[42][43]

He is a member of National Academy of Inventors, the International Academy of Medical and Biological Engineering, Canadian Academy of Engineering as well as the Royal Society of Canada.[44] He is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), Biomedical Engineering Society (BMES), Royal Society of Chemistry, Biomaterials Science and Engineering (FBSE), Materials Research Society (MRS), and American Association for the Advancement of Science (AAAS).

References
  1. "Terasaki Institute Welcomes New Director". Retrieved 28 August 2023.
  2. "Advanced Science Hall of Fame". Retrieved 28 August 2023.
  3. "Boston Scientific Announces Acquisition of Obsidio, Inc".
  4. "Omeat emerges from stealth with beefy tech approach to cultivated meat growth media".
  5. "Ali Khademhosseini - Google Scholar Citations". scholar.google.com. Retrieved 2017-09-12.
  6. "The World's Most Influential Scientific Minds 2015-Thomson Reuters (2016).pdf | Citation | Science". Scribd. Retrieved 2018-03-03.
  7. "Ali Khademhosseini citation rankings". Exaly. Retrieved 2022-06-07.
  8. "ACS Axial: Ali Khademhosseini's Personal Story of Discovery". Retrieved 28 August 2023.
  9. "Ali Khademhosseini: A Global Leader in Biomaterials and Tissue Engineering". Retrieved 28 August 2023.
  10. "Ali Khademhosseini: The path to 3D printing artificial vessels and more". Retrieved 28 August 2023.
  11. "ACS Axial: Ali Khademhosseini's Personal Story of Discovery". Retrieved 28 August 2023.
  12. Nichol, Jason W.; Koshy, Sandeep T.; Bae, Hojae; Hwang, Chang M.; Yamanlar, Seda; Khademhosseini, Ali (July 2010). "Cell-laden microengineered gelatin methacrylate hydrogels". Biomaterials. 31 (21): 5536–5544. doi:10.1016/j.biomaterials.2010.03.064. ISSN 0142-9612. PMC 2878615. PMID 20417964.
  13. Shin, Su Ryon; Bae, Hojae; Cha, Jae Min; Mun, Ji Young; Chen, Ying-Chieh; Tekin, Halil; Shin, Hyeongho; Zarabi, Sidney; Dokmeci, Mehmet R.; Tang, Shirley; Khademhosseini, Ali (2011-11-26). "Carbon Nanotube Reinforced Hybrid Microgels as Scaffold Materials for Cell Encapsulation". ACS Nano. 6 (1): 362–372. doi:10.1021/nn203711s. ISSN 1936-0851. PMC 3401631. PMID 22117858.
  14. Shin, Su Ryon; Jung, Sung Mi; Zalabany, Momen; Kim, Keekyoung; Zorlutuna, Pinar; Kim, Sang bok; Nikkhah, Mehdi; Khabiry, Masoud; Azize, Mohamed; Kong, Jing; Wan, Kai-tak; Palacios, Tomas; Dokmeci, Mehmet R.; Bae, Hojae; Tang, Xiaowu (Shirley) (2013-02-22). "Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators". ACS Nano. 7 (3): 2369–2380. doi:10.1021/nn305559j. ISSN 1936-0851. PMC 3609875. PMID 23363247.
  15. Shin, Su Ryon; Zihlmann, Claudio; Akbari, Mohsen; Assawes, Pribpandao; Cheung, Louis; Zhang, Kaizhen; Manoharan, Vijayan; Zhang, Yu Shrike; Yüksekkaya, Mehmet; Wan, Kai‐tak; Nikkhah, Mehdi; Dokmeci, Mehmet R.; Tang, Xiaowu (Shirley); Khademhosseini, Ali (2016-06-02). "Reduced Graphene Oxide‐GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering". Small. 12 (27): 3677–3689. doi:10.1002/smll.201600178. ISSN 1613-6810. PMC 5201005. PMID 27254107.
  16. Shin, Su Ryon; Aghaei-Ghareh-Bolagh, Behnaz; Dang, Tram T.; Topkaya, Seda Nur; Gao, Xiguang; Yang, Seung Yun; Jung, Sung Mi; Oh, Jong Hyun; Dokmeci, Mehmet R.; Tang, Xiaowu Shirley; Khademhosseini, Ali (November 2013). "Cell-laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide". Advanced Materials. 25 (44): 6385–6391. Bibcode:2013AdM....25.6385S. doi:10.1002/adma.201301082. PMC 3898458. PMID 23996513.
  17. "Engineering a highly elastic human protein–based sealant for surgical applications". Science Translational Medicine. 10 (470). 2018-12-05. doi:10.1126/scitranslmed.aai7466. ISSN 1946-6234. PMID 30518609.
  18. Mecwan, Marvin; Haghniaz, Reihaneh; Najafabadi, Alireza Hassani; Mandal, Kalpana; Jucaud, Vadim; John, Johnson V.; Khademhosseini, Ali (2023). "Thermoresponsive shear-thinning hydrogel (T-STH) hemostats for minimally invasive treatment of external hemorrhages". Biomaterials Science. 11 (3): 949–963. doi:10.1039/d2bm01559e. ISSN 2047-4830. PMID 36537259. S2CID 254487241.
  19. "Insight into the Progress of Biomedicine and Stem Cell Bioengineering at Harvard Medical School with Ali Khademhosseini". Retrieved 28 August 2023.
  20. Liu, Wanjun; Zhang, Yu Shrike; Heinrich, Marcel A.; De Ferrari, Fabio; Jang, Hae Lin; Bakht, Syeda Mahwish; Alvarez, Mario Moisés; Yang, Jingzhou; Li, Yi-Chen; Trujillo-de Santiago, Grissel; Miri, Amir K.; Zhu, Kai; Khoshakhlagh, Parastoo; Prakash, Gyan; Cheng, Hao (January 2017). "Bioprinting: Rapid Continuous Multimaterial Extrusion Bioprinting (Adv. Mater. 3/2017)". Advanced Materials. 29 (3). doi:10.1002/adma.201770016. ISSN 0935-9648.
  21. Miri, Amir K.; Nieto, Daniel; Iglesias, Luis; Goodarzi Hosseinabadi, Hossein; Maharjan, Sushila; Ruiz-Esparza, Guillermo U.; Khoshakhlagh, Parastoo; Manbachi, Amir; Dokmeci, Mehmet Remzi; Chen, Shaochen; Shin, Su Ryon; Zhang, Yu Shrike; Khademhosseini, Ali (July 2018). "Bioprinting: Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting (Adv. Mater. 27/2018)". Advanced Materials. 30 (27): 1870201. Bibcode:2018AdM....3070201M. doi:10.1002/adma.201870201. ISSN 0935-9648. S2CID 139999333.
  22. Zhu, Kai; Shin, Su Ryon; van Kempen, Tim; Li, Yi-Chen; Ponraj, Vidhya; Nasajpour, Amir; Mandla, Serena; Hu, Ning; Liu, Xiao; Leijten, Jeroen; Lin, Yi-Dong; Hussain, Mohammad Asif; Zhang, Yu Shrike; Tamayol, Ali; Khademhosseini, Ali (March 2017). "Tissue Engineering: Gold Nanocomposite Bioink for Printing 3D Cardiac Constructs (Adv. Funct. Mater. 12/2017)". Advanced Functional Materials. 27 (12). doi:10.1002/adfm.201770077. ISSN 1616-301X.
  23. Liu, Wanjun; Heinrich, Marcel A.; Zhou, Yixiao; Akpek, Ali; Hu, Ning; Liu, Xiao; Guan, Xiaofei; Zhong, Zhe; Jin, Xiangyu; Khademhosseini, Ali; Zhang, Yu Shrike (June 2017). "Extrusion Bioprinting of Shear‐Thinning Gelatin Methacryloyl Bioinks". Advanced Healthcare Materials. 6 (12): 1601451. doi:10.1002/adhm.201601451. ISSN 2192-2640. PMC 5545786. PMID 28464555.
  24. "Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors". Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1612906114. PMC 5373350.
  25. Shin, Su Ryon; Kilic, Tugba; Zhang, Yu Shrike; Avci, Huseyin; Hu, Ning; Kim, Duckjin; Branco, Cristina; Aleman, Julio; Massa, Solange; Silvestri, Antonia; Kang, Jian; Desalvo, Anna; Hussaini, Mohammed Abdullah; Chae, Su‐Kyoung; Polini, Alessandro (May 2017). "Label‐Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes". Advanced Science. 4 (5): 1600522. doi:10.1002/advs.201600522. ISSN 2198-3844. PMC 5441508. PMID 28546915.
  26. Shin, Su Ryon; Zhang, Yu Shrike; Kim, Duck-Jin; Manbohi, Ahmad; Avci, Huseyin; Silvestri, Antonia; Aleman, Julio; Hu, Ning; Kilic, Tugba; Keung, Wendy; Righi, Martina; Assawes, Pribpandao; Alhadrami, Hani A.; Li, Ronald A.; Dokmeci, Mehmet R. (2016-10-04). "Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers". Analytical Chemistry. 88 (20): 10019–10027. doi:10.1021/acs.analchem.6b02028. ISSN 0003-2700. PMC 5844853. PMID 27617489.
  27. Mousavi Shaegh, Seyed Ali; De Ferrari, Fabio; Zhang, Yu Shrike; Nabavinia, Mahboubeh; Binth Mohammad, Niema; Ryan, John; Pourmand, Adel; Laukaitis, Eleanor; Banan Sadeghian, Ramin; Nadhman, Akhtar; Shin, Su Ryon; Nezhad, Amir Sanati; Khademhosseini, Ali; Dokmeci, Mehmet Remzi (July 2016). "A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices". Biomicrofluidics. 10 (4): 044111. doi:10.1063/1.4955155. ISSN 1932-1058. PMC 5001973. PMID 27648113.
  28. Mostafalu, Pooria; Tamayol, Ali; Rahimi, Rahim; Ochoa, Manuel; Khalilpour, Akbar; Kiaee, Gita; Yazdi, Iman K.; Bagherifard, Sara; Dokmeci, Mehmet R.; Ziaie, Babak; Sonkusale, Sameer R.; Khademhosseini, Ali (August 2018). "Smart Bandages: Smart Bandage for Monitoring and Treatment of Chronic Wounds (Small 33/2018)". Small. 14 (33): 1870150. doi:10.1002/smll.201870150. ISSN 1613-6810. S2CID 139363378.
  29. Bertassoni, Luiz E.; Cecconi, Martina; Manoharan, Vijayan; Nikkhah, Mehdi; Hjortnaes, Jesper; Cristino, Ana Luiza; Barabaschi, Giada; Demarchi, Danilo; Dokmeci, Mehmet R.; Yang, Yunzhi; Khademhosseini, Ali (2014). "Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs". Lab Chip. 14 (13): 2202–2211. doi:10.1039/c4lc00030g. ISSN 1473-0197. PMC 4201051. PMID 24860845.
  30. Sadr, Nasser; Zhu, Mojun; Osaki, Tatsuya; Kakegawa, Takahiro; Yang, Yunzhi; Moretti, Matteo; Fukuda, Junji; Khademhosseini, Ali (October 2011). "SAM-based cell transfer to photopatterned hydrogels for microengineering vascular-like structures". Biomaterials. 32 (30): 7479–7490. doi:10.1016/j.biomaterials.2011.06.034. PMC 3156389. PMID 21802723.
  31. Miri, Amir K.; Khalilpour, Akbar; Cecen, Berivan; Maharjan, Sushila; Shin, Su Ryon; Khademhosseini, Ali (April 2019). "Multiscale bioprinting of vascularized models". Biomaterials. 198: 204–216. doi:10.1016/j.biomaterials.2018.08.006. PMC 6360139. PMID 30244825.
  32. "Khademhosseini and Team Develop Tissue-Based Soft Robot". Retrieved 28 August 2023.
  33. "Ali Khademhosseini - Google Scholar Citations". scholar.google.com. Retrieved 2017-09-12.
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  37. "Omeat emerges from stealth with beefy tech approach to cultivated meat growth media".
  38. "Cultivated meat from cows: How Omeat uses plasma to grow beef".
  39. "Why this lab-meat startup is keeping cows in the equation".
  40. "President Obama Honors Outstanding Early-Career Scientists". Office of the Press Secretary. 2011-09-26. Retrieved 26 September 2011.
  41. "TR35".
  42. "Mustafa Prize 2019". Retrieved 2020-10-21.
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  44. "Two professors elected fellows of the Royal Society of Canada".
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