Alkb homolog 3, alpha-ketoglutaratedependent dioxygenase

AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase is a protein that in humans is encoded by the ALKBH3 gene. [5]

ALKBH3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesALKBH3, ABH3, DEPC-1, DEPC1, PCA1, hABH3, alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase, alkB homolog 3, alpha-ketoglutaratedependent dioxygenase, alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
External IDsOMIM: 610603 MGI: 1916363 HomoloGene: 16393 GeneCards: ALKBH3
Orthologs
SpeciesHumanMouse
Entrez

221120

69113

Ensembl

ENSG00000166199

ENSMUSG00000040174

UniProt

Q96Q83

Q8K1E6

RefSeq (mRNA)

NM_139178

NM_026944

RefSeq (protein)

NP_631917

NP_081220

Location (UCSC)Chr 11: 43.88 – 43.92 MbChr 2: 93.81 – 93.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).

References

  1. GRCh38: Ensembl release 89: ENSG00000166199 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040174 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase". Retrieved 2017-03-04.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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