Alpha-bisabolene synthase

α-Bisabolene synthase (EC 4.2.3.38, bisabolene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E)-α-bisabolene-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate (E)-α-bisabolene + diphosphate
α-isabolene synthase
Identifiers
EC no.4.2.3.38
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group.

References

  1. Bohlmann J, Crock J, Jetter R, Croteau R (June 1998). "Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-alpha-bisabolene synthase from grand fir (Abies grandis)". Proceedings of the National Academy of Sciences of the United States of America. 95 (12): 6756–61. Bibcode:1998PNAS...95.6756B. doi:10.1073/pnas.95.12.6756. PMC 22624. PMID 9618485.
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