Alternative ribosome-rescue factor B

Alternative ribosome-rescue factor B (ArfB, YaeJ) also known as peptidyl-tRNA hydrolase,[1] is a protein that plays a role in rescuing of stalled ribosomes.[1] It works like a GGQ-release factor itself, releasing the peptide from tRNA.[2] At the same time, it fits into the mRNA tunnel to remove the mRNA.[3]

Peptidyl-tRNA hydrolase ArfB
Identifiers
OrganismE. coli
SymbolArfB
UniProtP40711
Search for
StructuresSwiss-model
DomainsInterPro

This gene is also found in eukaryotic organelles as MRPL58 (ICT1). The similarity is high enough to be interchangeable.[4] Its role has expanded to that of a codon-independent release factor, although it likely still functions in ribosomal rescue.[5]

See also

References
  1. "Peptidyl-tRNA hydrolase, ribosome rescue factor". BioCyc. SRI International.
  2. Chan KH, Petrychenko V, Mueller C, Maracci C, Holtkamp W, Wilson DN, et al. (August 2020). "Mechanism of ribosome rescue by alternative ribosome-rescue factor B". Nature Communications. 11 (1): 4106. Bibcode:2020NatCo..11.4106C. doi:10.1038/s41467-020-17853-7. PMC 7427801. PMID 32796827.
  3. Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA (November 2020). "ArfB can displace mRNA to rescue stalled ribosomes". Nature Communications. 11 (1): 5552. Bibcode:2020NatCo..11.5552C. doi:10.1038/s41467-020-19370-z. PMC 7641280. PMID 33144582.
  4. Feaga HA, Quickel MD, Hankey-Giblin PA, Keiler KC (March 2016). "Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria". PLOS Genetics. 12 (3): e1005964. doi:10.1371/journal.pgen.1005964. PMC 4814080. PMID 27029019.
  5. Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, et al. (March 2010). "A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome". The EMBO Journal. 29 (6): 1116–1125. doi:10.1038/emboj.2010.14. PMC 2845271. PMID 20186120.
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