Periampullary cancer

Periampullary cancer is a cancer that forms near the ampulla of Vater, an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine.[1] It consists of:

  1. ampullary tumour from ampulla of Vater
  2. cancer of lower common bile duct
  3. duodenal cancer adjacent to ampulla
  4. carcinoma head of pancreas
Periampullary cancer
Ampulla of Vater
SpecialtyOncology

It presents with painless jaundice which may have waxing and waning nature because at times the sloughing of the tumor tissue relieves the obstruction partially.

Signs and symptoms of periampullary cancer[2]

  • Jaundice (yellowing of skin, eyes and urine with pale stools)
  • Itching
  • Abdominal pain
  • Weight loss and loss of appetite
  • Recurrent vomiting
  • Black stools
  • Anaemia

Treatment[2]

The treatment depends upon the stage of the disease and degree of jaundice. Surgery is the best possible option and can be considered if the cancer is diagnosed at a stage where it can be completely removed by surgery. If the jaundice is very high, your surgeon may choose to decrease jaundice before surgery by doing a procedure called endoscopic retrograde cholangiopancreatography (ERCP) and stenting. In this, a plastic or metallic tube called stent is placed in the bile duct which is blocked by tumour and opens it up from inside.

If the tumour is advanced, then he may also give you neoadjuvant treatment (chemotherapy or chemoradiotherapy) to decrease the size of the tumour and then resect it to increase your chances of survival.

For unresectable tumours, an attempt to made to downstage them to a stage where they can be surgically removed. For this neoadjuvant treatment is administered and some of these patients will become operable.

Surgery[2]

The operation to surgically remove periampullary cancer is called Whipple operation[3] or pancreaticoduodenectomy.[3] In this, the head of the pancreas is removed along with duodenum, bile duct, gall bladder, part of the stomach, a small part of the small intestine and adjacent lymph nodes. To restore gastrointestinal continuity, the small intestine is then joined to the pancreas (sometimes pancreas is joined to the stomach), remaining bile duct and stomach.

See also

Notes
  1. "Periampullary cancer". Dictionary of Cancer Terms. National Cancer Institute. Retrieved 31 August 2013. Quoted material is in the public domain.
  2. "Periampullary Cancer: Symptoms, Staging & Treatment | Dr. Nikhil Agrawal". Dr.Nikhil Agrawal. Retrieved 2023-01-02.
  3. "Whipple Procedure or Pancreaticoduodenectomy | Dr.Nikhil Agrawal". Dr. Nikhil Agrawal. Retrieved 2023-01-02.
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