Intraepithelial neoplasia

Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an epithelium. The exact dividing line between dysplasia and neoplasia has been very difficult to draw throughout the era of medical science. It varies between persons. In the localizations shown below, the term intraepithelial neoplasia is used to describe more accurately what was historically referred to as epithelial dysplasia. IEN is not cancer, but it is associated with higher risk for developing cancer in future. It is thus sometimes a precancerous condition.

High grade anal intraepithelial neoplasia.
Progression of pancreatic intraepithelial neoplasia, including mutations.[1]

Localizations
LocalizationUsual acronym
anal intraepithelial neoplasiaAIN
biliary intraepithelial neoplasiaBILIN
cervical intraepithelial neoplasiaCIN
endometrial intraepithelial neoplasiaEIN
gastrointestinal intraepithelial neoplasia[2]GIN
pancreatic intraepithelial neoplasiaPanIN
penile intraepithelial neoplasiaPEIN
prostatic intraepithelial neoplasiaPIN
vaginal intraepithelial neoplasiaVIN
vulvar intraepithelial neoplasiaVIN

References
  1. Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016). "Surgical and molecular pathology of pancreatic neoplasms". Diagn Pathol. 11 (1): 47. doi:10.1186/s13000-016-0497-z. PMC 4897815. PMID 27267993.{{cite journal}}: CS1 maint: multiple names: authors list (link)
    - "This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)"
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  2. Schlemper, RJ; et al. (2000). "The Vienna classification of gastrointestinal epithelial neoplasia". Gut. 47 (2): 251–5. doi:10.1136/gut.47.2.251. PMC 1728018. PMID 10896917.


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