Andrea Baccarelli

Andrea Baccarelli (born December 6, 1970) is an Italian American epigeneticist and clinical endocrinologist, best known for his academic contributions in the field of epigenetics, mitochondriomics, and computational epigenomics, with a research focus on investigating the impact of environmental exposures on human health.[1] He serves as Professor and Chair of the Department of Environmental Health Sciences at the Columbia University Mailman School of Public Health.[2][3]

Andrea Baccarelli
BornDecember 6, 1970
Italy
NationalityItalian
CitizenshipAmerican, Italian (Dual citizenship)
EducationPhD, University of Milan

MPH, University of Turin

MD, University of Perugia
Scientific career
FieldsEnvironmental health sciences, epigenetics, mitochondriomics, and computational epigenomics
InstitutionsNational Cancer Institute’s Division of Cancer Epidemiology and Genetics
Universita' degli Studi di Milano
Harvard School of Public Health
Columbia University Mailman School of Public Health

Education and career

Baccarelli obtained his Master of Science in Epidemiology from the University of Turin, Italy, in 2000 and his Ph.D. in Molecular Epidemiology from the Universita' degli Studi di Milano, Italy, in 2003.[4]

He completed his residency in endocrinology at the University of Milan and his postdoctoral fellowship at the National Cancer Institute’s Division of Cancer Epidemiology and Genetics (2000-2004).[5]

Baccarelli has served as the Environmental Health Sciences Department Chair and the Director of the Laboratory of Precision Environmental Biosciences at the Columbia University Mailman School of Public Health since 2016.[6][7] Prior to joining Columbia University in 2016, he was the Mark and Catherine Winkler Associate Professor of Environmental Epigenetics at the Harvard School of Public Health.[8]

He was elected to the National Academy of Medicine and as President of the International Society of Environmental Epidemiology in 2020.[9]

Baccarelli's research has pioneered the field of public health epigenetics, which explores how environmental factors can modify gene expression without changing the DNA sequence.[10] His studies have demonstrated that air pollution can alter the epigenome, leading to changes in gene regulation that contribute to the development of diseases such as cardiovascular disorders and neurodegenerative conditions.[11][12]

Baccarelli conducted research showing that short-term exposure to air pollution, including levels considered "acceptable," can impair cognitive ability in the elderly.[13][14][15] Baccarelli also found that the use of nonsteroidal anti-inflammatory drugs such as aspirin partially protected against the negative cognitive effects of pollution.[16] He also conducted research showing that ambient air pollution is associated with an increased risk of osteoporosis and bone fractures in older individuals.[17][18]

Awards and recognition

Baccarelli was recognized as the “Person of the Year” by the City of Perugia, Italy.[19][20]

Selected publications
  • Baccarelli A, Bollati V. Epigenetics and environmental chemicals. Curr Opin Pediatr. 2009 Apr;21(2):243-51.[21]
  • Marioni, R.E., Shah, S., McRae, A.F. et al. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol 16, 25 (2015).[22]
  • Baccarelli, Andrea; Wright, Robert O.; Bollati, Valentina. et al. "Rapid DNA Methylation Changes after Exposure to Traffic Particles".[23]
  • Bollati, Valentina, et al. "Changes in DNA methylation patterns in subjects exposed to low-dose benzene." Cancer research 67.3 (2007): 876-880.[24]
  • Levine, Morgan E., et al. "An epigenetic biomarker of aging for lifespan and healthspan." Aging (Albany NY) 10.4 (2018): 573.[25]

References
  1. "Andrea A. Baccarelli". scholar.google.com. Retrieved 2021-10-21.
  2. "Air pollution spikes may impair older men's thinking, study finds". the Guardian. 2021-05-03. Retrieved 2021-10-21.
  3. ""C'è una relazione tra inquinamento e capacità cognitive"". la Repubblica (in Italian). 2021-05-21. Retrieved 2021-10-21.
  4. "Una vita per la ricerca, Il Baiocco d'oro a Baccarelli". Tuttoggi (in Italian). 2018-08-21. Retrieved 2021-10-22.
  5. "Andrea Baccarelli | Columbia Public Health". www.publichealth.columbia.edu. Retrieved 2021-10-21.
  6. Naish, John. "In the office or dining out — how clean is the air you breathe?". The Times. ISSN 0140-0460. Retrieved 2021-10-21.
  7. Oliveira, Alexandra (2020-09-28). "Five environmental policy questions that should be asked in the presidential debates". TheHill. Retrieved 2021-10-21.
  8. Kirkpatrick, Bailey (2016-07-28). "3 Pioneering Epigenetic Labs: Exploring the People and Discoveries that Transcend the Lab Walls". What is Epigenetics?. Retrieved 2021-10-22.
  9. "Five Elected to the National Academy of Medicine". Columbia University Irving Medical Center. 2020-10-16. Retrieved 2021-10-21.
  10. Kirkpatrick, Bailey (2016-07-28). "3 Pioneering Epigenetic Labs: Exploring the People and Discoveries that Transcend the Lab Walls". What is Epigenetics?. Retrieved 2023-06-22.
  11. Kirkpatrick, Bailey (2017-05-30). "B Vitamins Protect Against Harmful Epigenetic Effects of Air Pollution". What is Epigenetics?. Retrieved 2023-06-22.
  12. #author.fullName}. "How our environment is making us sick – and what we can do about it". New Scientist. Retrieved 2023-06-22. {{cite web}}: |last= has generic name (help)
  13. Bakalar, Nicholas (2021-05-17). "Air Pollution Takes a Toll on the Brain". The New York Times. ISSN 0362-4331. Retrieved 2023-06-22.
  14. "Short-term exposure to air pollution may impede cognition, Aspirin could help: Study". in.style.yahoo.com. 2021-05-04. Retrieved 2023-06-22.
  15. Sample, Ian; editor, Ian Sample Science (2021-05-03). "Air pollution spikes may impair older men's thinking, study finds". The Guardian. ISSN 0261-3077. Retrieved 2023-06-22. {{cite news}}: |last2= has generic name (help)
  16. Sample, Ian; editor, Ian Sample Science (2021-05-03). "Air pollution spikes may impair older men's thinking, study finds". The Guardian. ISSN 0261-3077. Retrieved 2023-06-22. {{cite news}}: |last2= has generic name (help)
  17. "Does air pollution affect osteoporosis? Science finds a connection". Fortune Well. Retrieved 2023-06-22.
  18. www.ETHealthworld.com. "Air pollution speeds up bone loss from osteoporosis: Study - ET HealthWorld". ETHealthworld.com. Retrieved 2023-06-22.
  19. "Perugia consegna il Baiocco d'oro al professor Andrea Baccarelli: "È uno dei nostri figli migliori"". Umbria24.it (in Italian). Retrieved 2021-10-22.
  20. "Baiocco d'Oro al super professore perugino: "Oggi la città premia uno dei suoi figli migliori"". PerugiaToday (in Italian). Retrieved 2021-10-22.
  21. Baccarelli, Andrea; Bollati, Valentina (2009). "Epigenetics and environmental chemicals". Current Opinion in Pediatrics. 21 (2): 243–251. doi:10.1097/MOP.0b013e32832925cc. ISSN 1040-8703. PMC 3035853. PMID 19663042.
  22. Marioni, Riccardo E; Shah, Sonia; McRae, Allan F; Chen, Brian H; Colicino, Elena; Harris, Sarah E; Gibson, Jude; Henders, Anjali K; Redmond, Paul; Cox, Simon R; Pattie, Alison (2015). "DNA methylation age of blood predicts all-cause mortality in later life". Genome Biology. 16 (1): 25. doi:10.1186/s13059-015-0584-6. ISSN 1474-760X. PMC 4350614. PMID 25633388.
  23. Baccarelli, Andrea; Wright, Robert O.; Bollati, Valentina; Tarantini, Letizia; Litonjua, Augusto A.; Suh, Helen H.; Zanobetti, Antonella; Sparrow, David; Vokonas, Pantel S.; Schwartz, Joel (2009). "Rapid DNA Methylation Changes after Exposure to Traffic Particles". American Journal of Respiratory and Critical Care Medicine. 179 (7): 572–578. doi:10.1164/rccm.200807-1097OC. ISSN 1073-449X. PMC 2720123. PMID 19136372.
  24. Bollati, Valentina; Baccarelli, Andrea; Hou, Lifang; Bonzini, Matteo; Fustinoni, Silvia; Cavallo, Domenico; Byun, Hyang-Min; Jiang, Jiayi; Marinelli, Barbara; Pesatori, Angela C.; Bertazzi, Pier A. (2007-02-01). "Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene". Cancer Research. 67 (3): 876–880. doi:10.1158/0008-5472.CAN-06-2995. hdl:11383/1708214. ISSN 0008-5472. PMID 17283117. S2CID 15163723.
  25. Levine, Morgan E.; Lu, Ake T.; Quach, Austin; Chen, Brian H.; Assimes, Themistocles L.; Bandinelli, Stefania; Hou, Lifang; Baccarelli, Andrea A.; Stewart, James D.; Li, Yun; Whitsel, Eric A. (2018-04-18). "An epigenetic biomarker of aging for lifespan and healthspan". Aging. 10 (4): 573–591. doi:10.18632/aging.101414. ISSN 1945-4589. PMC 5940111. PMID 29676998.
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