Annie Curtis

Curtis completed a B.A in Genetics in Trinity College Dublin (1994-1998) and conducted her PhD in the laboratory of Prof. Garret FitzGerald in Pharmacology (2001 – 2006) at University of Pennsylvania.[1] Here she became aware of body clocks and found out how the clock controls cardiovascular function.[2][3]

Curtis was recruited to GlaxoSmithKline in Philadelphia as a Principal Scientist directly after completing her PhD, where she led a small research team researching biomarkers for cardiovascular risk between 2006–2008.[4] In 2008 she was recruited as Scientific Programme Manager for Science Foundation Ireland (SFI) until 2010 when she was employed as Medical Advisor for Immunotherapeutics with Bristol-Myers Squibb.[4]

In 2011, she joined the laboratory of Luke O'Neill in biochemistry at Trinity College Dublin.[4] In 2014, she was awarded an SFI Starting Investigator Research Grant to establish a group studying the impact of clocks on the immune system.[1] Curtis joined the Royal College of Surgeons in Ireland as a research lecturer in Molecular and Cellular Therapeutics in August 2016.[1][5] Her work has led to the understanding of mechanisms inducing chronic inflammatory diseases like multiple sclerosis which is linked to the disruption of the body clock.[6]

• Curtis, Anne M.; Seo, Sang-beom; Westgate, Elizabeth J.; Rudic, Radu Daniel; Smyth, Emer M.; Chakravarti, Debabrata.; FitzGerald, Garret A.; McNamara, Peter., "HAT-dependent chromatin remodeling and the vascular clock", American Society for Biochemistry and Molecular Biology 2003
• Rudic, R Daniel; McNamara, Peter; Curtis, Anne-Maria; Boston, Raymond C.; Panda, Satchidananda; Hogenesch, John B.; FitzGerald, Garret A., "BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis", PLoS Biology 2004; 11: e377
• Curtis, Anne M.; Cheng, Yan; Kapoor, Shiv; Reilly, Dermot; Price, Tom S.; FitzGerald, Garret A., "Circadian variation of blood pressure and the vascular response to asynchronous stress", National Academy of Sciences 2007; 104; 3450-3455
• FitzGerald, G.A.; Curtis, A.M., "Central and peripheral clocks in cardiovascular and metabolic function", Annals of Medicine 2006; 38: 552-559
• Tannahill, G.M.; Curtis, A.M.; Adamik J., Palsson-McDermott, E.M.; McGettrick, A.F.; Goel G.; Frezza, C.; Bernard, N.J.; Kelly, B.; Foley, N.H.; Zheng, L.; Gardet, A.; Tong, Z.; Jany, S.S.; Corr, S.C.; Haneklaus, M.; Caffrey, B.E.; Pierce, K.; Walmsley, S.; Beasley, F.C.; Cummins, E.; Nizet, V.; Whyte, M.; Taylor, C.T.; Lin, H.; Masters S.L.; Gottlieb E.; Kelly V.P.; Clish C.; Auron P.E.; Xavier R.J.; O'Neill L.A.J., "Succinate is an inflammatory signal that induces IL-1β through HIF-1α", Nature, 2013; 496, 238.
• Curtis, Anne M.; Bellet, Marina M.; Sassone-Corsi, Paolo; O'Neill, Luke A.J., "Circadian clock proteins and immunity", Immunity 2014; 40: 178-186
• Palsson-McDermott, Eva M.; Curtis, Anne M.; Goel, Gautam; Lauterbach, Mario A.R.; Sheedy, Frederick J.;Gleeson, Laura E.; van den Bosch, Mirjam W.M.; Quinn, Susan R.; Domingo-Fernandez, Raquel; Johnston, Daniel G.W.; Jiang, Jian-kang; Israelsen, William J.; Keane, Joseph; Thomas, Craig; Clish, Clary; Vander Heiden, Matthew; Xavier, Ramnik J.; O'Neill, Luke A.J., "Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages", Cell Metabolism 2015; 21: 65-80
• Curtis A.M., Early, J.O.; "Immunometabolism: Is it under the eye of the clock?", Seminars in immunology 2016; 28: 478-490[7]

2017: L'Oréal-UNESCO For Women in Science UK & Ireland Fellowships 2017 Fellowship, L'Oréal-UNESCO[8]

2012: Winner, Roche Medal, Researcher of the Year, Trinity Biomedical Science Institute, Roche Pharmaceuticals[9]

2006: Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Junior Investigator Award for Women 2006, ATVB