Anoctamin 6

Anoctamin 6 is a protein that in humans is encoded by the ANO6 gene. [5]

ANO6
Identifiers
AliasesANO6, BDPLT7, SCTS, TMEM16F, anoctamin 6
External IDsOMIM: 608663 MGI: 2145890 HomoloGene: 27888 GeneCards: ANO6
Orthologs
SpeciesHumanMouse
Entrez

196527

105722

Ensembl

ENSG00000177119

ENSMUSG00000064210

UniProt

Q4KMQ2

Q6P9J9

RefSeq (mRNA)

NM_001025356
NM_001142678
NM_001142679
NM_001142680
NM_001204803

NM_001253813
NM_175344

RefSeq (protein)

NP_001020527
NP_001136150
NP_001136151
NP_001191732

NP_001240742
NP_780553

Location (UCSC)Chr 12: 45.22 – 45.48 MbChr 15: 95.69 – 95.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research

The protein may play a role in syncytia formation during COVID-19 infection.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000177119 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000064210 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Anoctamin 6". Retrieved 2017-09-28.
  6. Braga, Luca; Ali, Hashim; Secco, Ilaria; Chiavacci, Elena; Neves, Guilherme; Goldhill, Daniel; Penn, Rebecca; Jimenez-Guardeño, Jose M.; Ortega-Prieto, Ana M.; Bussani, Rossana; Cannatà, Antonio; Rizzari, Giorgia; Collesi, Chiara; Schneider, Edoardo; Arosio, Daniele; Shah, Ajay M.; Barclay, Wendy S.; Malim, Michael H.; Burrone, Juan; Giacca, Mauro (2021). "Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia". Nature. 594 (7861): 88–93. Bibcode:2021Natur.594...88B. doi:10.1038/s41586-021-03491-6. ISSN 0028-0836. PMC 7611055. PMID 33827113.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q6P9J9 (Mouse Anoctamin-6) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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