Antisaccade task

The anti-saccade (AS) task is a way of measuring how well the frontal lobe of the brain can control the reflexive saccade, or eye movement.[1] Saccadic eye movement is primarily controlled by the frontal cortex.

Antisaccade task
PurposeDetect dysfunction of the frontal lobe

Use

Research in pathophysiology

Saccadic eye movements and anti-saccadic eye movements are carried out by similar regions of the brain: the frontal eye field (FEF), the supplementary motor area (SMA), the thalamus and putamen. Anti-saccades involve two important cognitive functions: the ability to form an intention and the ability to inhibit a reflexive response. It was therefore thought that the dorsolateral prefrontal cortex played a greater role in anti-saccadic movements.

This theory was disproved by O’Driscoll et al. in a study that used positron emission tomography to analyze brain activity during anti-saccadic movement. The study showed that the DLPFC was equally activated in both saccadic and anti-saccadic movements. Anti-saccades required increased activation of the FEF, SMA and putamen.[2]

Currently, the anti-saccade task is currently used as a relatively crude or basic assessment of frontal lobe function in patients with neurological or psychiatric disorders. The task has high sensitivity, meaning that it is good at detecting frontal lobe dysfunction. However, its specificity is low, meaning that it can also be positive in patients without frontal lobe dysfunction.[1] Of note, children and adults over the age of 70 will physiologically have an increased rate of error on the anti-saccade task.

Psychological research

Modified versions of the task, often termed as emotional antisaccade task, have been used in psychological and psychophysiological research to investigate the interaction between visual attention and the processing of emotions. Emotion drives attention: people are usually biased to direct eye movements towards emotional rather than neutral and dull stimuli. The emotional version of the antisaccade task uses emotional stimuli (photographs or conditioned stimuli) as visual targets, requiring participants to look in the opposite direction.[3] Performance in the task is a measure for attentional biases in healthy participants[4] and various disorders such as mood disorders,[5] addiction [6] and social anxiety.[7]

Procedure

To perform the anti-saccade task, an individual is asked to fixate on a motionless target (such as a small dot). A stimulus is then presented to one side of the target. The individual is asked to make a saccade in the direction away from the stimulus. For example, if a stimulus is presented to the left of the motionless target, the patient should look toward the right. Failure to inhibit a reflexive saccade is considered an error.[1]

Neurologic disorders affecting both the frontal cortex or the basal ganglia have shown impaired performance on the anti-saccade task. These include schizophrenia, Huntington's disease, Parkinson's disease, and progressive supranuclear palsy. Additionally, disseminated brain disease such as Alzheimer's disease or AIDS dementia also have an increased number of errors.[1]

History

The anti-saccade test was initially described in 1978 by Peter Hallet when he was a faculty member at the Department of Physiology of the University of Toronto.[8] Many other researchers have used this task, including Guitton et al. and Pierrot-Deseilligny et al. In a well-known study by Guitton et al. (1985), patients with epilepsy who had undergone therapeutic removal of their dorsolateral prefrontal cortex were administered the anti-saccade task. Their performance was compared to healthy controls and patients who had undergone therapeutic removal of their temporal lobes. Results from Guitton’s studies showed that only patients with frontal lobe lesions performed abnormally on the AS task.[9]

In contrast, studies by Pierrot-Deseilligny et al. correlated high error rates of AS to specific lesions in the dorsolateral prefrontal cortex (DLPFC). In this study, patients with unilateral infarctions of the posterior parietal lobe were compared against infarctions in 3 frontal regions: the supplementary motor area, frontal eye fields (FEF), and the DLPFC. Only patients with infarctions of the DLPFC showed statistically significant error rates.[10]

References
  1. Levy, D.; Mendell, N.; Holzman, P. (2004). "The antisaccade task and neuropsychological tests of prefrontal cortical integrity in schizophrenia: empirical findings and interpretative considerations". World Psychiatry. 3 (1): 32–40. PMC 1414662. PMID 16633452.
  2. O'Driscoll, G.; Alpert, N.; Mathysse, S.; Levy, S.; Rauch, S.; Holzmann, P. (1995). "Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomorgraphy". Proceedings of the National Academy of Sciences. 92 (3): 925–929. Bibcode:1995PNAS...92..925O. doi:10.1073/pnas.92.3.925. PMC 42733. PMID 7846080.
  3. Kissler, Johanna, and Andreas Keil. "Look–don’t look! How emotional pictures affect pro-and anti-saccades." Experimental Brain Research 188.2 (2008): 215-222.
  4. Deuter, C. E.; Schilling, T. M.; Kuehl, L. K.; Blumenthal, T. D.; Schachinger, H. (2013). "Startle effects on saccadic responses to emotional target stimuli". Psychophysiology. 50 (10): 1056–1063. doi:10.1111/psyp.12083. PMID 23841560.
  5. Ainsworth, B.; Garner, M. (2013). "Attention control in mood and anxiety disorders: evidence from the antisaccade task". Human Psychopharmacology: Clinical and Experimental. 28 (3): 274–280. doi:10.1002/hup.2320. PMID 23653434. S2CID 42743016.
  6. Wachter, N. J.; Gilbert, D. G. (2013). "Nicotine differentially modulates antisaccade eye-gaze away from emotional stimuli in nonsmokers stratified by pre-task baseline performance". Psychopharmacology. 225 (3): 561–568. doi:10.1007/s00213-012-2842-6. PMC 3547148. PMID 22955567.
  7. Wieser, M. J.; Pauli, P.; Mühlberger, A. (2009). "Probing the attentional control theory in social anxiety: An emotional saccade task". Cognitive, Affective, & Behavioral Neuroscience. 9 (3): 314–322. doi:10.3758/cabn.9.3.314. PMID 19679766.
  8. Hallett, P. E. (1978). "Primary and secondary saccades to goals defined by instructions". Vision Research. 18 (10): 1279–1296. doi:10.1016/0042-6989(78)90218-3. PMID 726270. S2CID 27735329.
  9. Guitton, D; Buchtel, HA; Douglas, RM (1985). "Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades" (PDF). Exp Brain Res. 58 (3): 455–472. doi:10.1007/bf00235863. hdl:2027.42/46554. PMID 4007089. S2CID 10551663.
  10. Pierrot-Deseilligny, C; Rivaud, S; Gaymard, B; et al. (1991). "Cortical control of reflexive visually-guided saccades". Brain. 114 (3): 1473–1485. doi:10.1093/brain/114.3.1473. PMID 2065261.
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